HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (3,4- dichlorophenyl)- 3- azabicyclo- (3.1.0)hexane hydrochloride

a triple uptake inhibitor; structure in first source

Also Known As:

DOV 21,947; DOV 216,303; DOV 216303; DOV 21947; DOV-21947; DOV21947; EB-1010; amitifadine

Networked: 13 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - 1-(3,4-dichlorophenyl)-3-azabicyclo-(3.1.0)hexane hydrochloride: 13
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - 1-(3,4-dichlorophenyl)-3-azabicyclo-(3.1.0)hexane hydrochloride: 13

Experts

1.	Skolnick, Phil: 3 articles (11/2012 - 03/2008)
2.	McKinney, Anthony: 2 articles (06/2020 - 01/2012)
3.	June, Harry L: 2 articles (03/2015 - 11/2012)
4.	Warnock, Kaitlin T: 2 articles (03/2015 - 11/2012)
5.	Basile, Anthony S: 2 articles (11/2012 - 03/2008)
6.	Blair, Graham: 1 article (06/2020)
7.	Hawkey, Andrew: 1 article (06/2020)
8.	Holloway, Zade: 1 article (06/2020)
9.	Ko, Ashley: 1 article (06/2020)
10.	Levin, Edward D: 1 article (06/2020)

Related Diseases

1.	Chronic Pain 06/01/2020 - "Further studies are needed to determine the possible efficacy of amitifadine for combating opiate addiction or preventing it in humans during adjunctive use with opioids for chronic pain."
2.	Opioid-Related Disorders (Opiate Addiction) 06/01/2020 - "Further studies are needed to determine the possible efficacy of amitifadine for combating opiate addiction or preventing it in humans during adjunctive use with opioids for chronic pain."
3.	Weight Gain 11/01/2012 - "In view of the safety profile of amitifadine in humans, including low risk for weight gain, lack of sexual side effects, and low potential for abuse, we hypothesize that amitifadine will be effective in treating co-occurring alcoholism and depression."
4.	Obesity 03/01/2008 - "In summary, DOV 21947 is effective in causing a sustained and selective reduction in fat content and triglyceride levels in animal models of obesity without significantly altering vital organ function." 03/01/2008 - "The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity." 03/01/2008 - "(1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo-[3.1.0] hexane hydrochloride (DOV 21947) inhibits norepinephrine, 5-hydroxytryptamine, and dopamine uptake, and it reduces body weight in rodent models of diet-induced obesity (DIO). "
5.	Alcoholism (Alcohol Abuse) 11/01/2012 - "In view of the safety profile of amitifadine in humans, including low risk for weight gain, lack of sexual side effects, and low potential for abuse, we hypothesize that amitifadine will be effective in treating co-occurring alcoholism and depression." 11/01/2012 - "Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology."

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Triglycerides (Triacylglycerol)
3.	Serotonin (5 Hydroxytryptamine)
4.	Norepinephrine (Noradrenaline)
5.	Dopamine (Intropin)
6.	Antidepressive Agents (Antidepressants)
7.	1- (3,4- dichlorophenyl)- 3- azabicyclo- (3.1.0)hexane hydrochloride
8.	Risperidone (Risperdal Consta)
9.	Dopamine Uptake Inhibitors (Dopamine Reuptake Inhibitors)
10.	Paroxetine (Paxil)