dunnione

RN given for (+)-isomer; an industrial fungicide; structure in first source

Networked: 9 relevant articles (2 outcomes, 2 trials/studies)

1.	Inflammation (Inflammations) 12/18/2018 - "In addition, caerulein-induced pancreatic inflammation and acinar cell injury were significantly reduced by dunnione treatment. " 07/01/2018 - "Dunnione repressed cisplatin-induced inflammation in the kidneys as indicated by decreased TNF-α/IL-1β levels, and reduced nuclear phosphorylated NF-κB p65. " 01/01/2022 - "Dunnione improved IMQ-induced epidermal hyperplasia and inflammation, consistent with decreased levels of inflammatory cytokines (IL-17, IL-22, and IL-23) in skin lesions. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2022 - "Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice." 01/01/2022 - "Moreover, we found that an increase in the NAD+/NADH ratio by dunnione restored SIRT1 activity, thereby reduced imiquimod-induced STAT3 acetylation, which modulates the expression of psoriasis-promoting inflammatory cytokines, such as IL-17, IL-22, and IL-23. "
3.	Hyperplasia 01/01/2022 - "Dunnione improved IMQ-induced epidermal hyperplasia and inflammation, consistent with decreased levels of inflammatory cytokines (IL-17, IL-22, and IL-23) in skin lesions. "
4.	Dermatitis 01/01/2022 - "Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice."
5.	Ototoxicity 03/01/2016 - "Dunnione ameliorates cisplatin ototoxicity through modulation of NAD(+) metabolism."

1.	Cisplatin (Platino)
2.	NAD (NADH)
3.	Cytokines
4.	Imiquimod (Aldara)
5.	Thromboplastin (Tissue Factor)
6.	Sirtuin 1
7.	Interleukin-23 (Interleukin 23)
8.	Interleukin-17 (Interleukin 17)
9.	NF-kappa B (NF-kB)
10.	Phenols