SB-710411

is purported to block U-II-induced contractions in rat isolated aorta, little is known about its specific pharmacological properties

Also Known As:

Cpa-c(D-Cys-Pal-D-Trp-Lys-Val-Cys)-Cpa-amide; chlorophenylalanyl-cyclo(cysteinyl-1-oxohexadecyl-tryptophyl-lysyl-valyl-cysteinyl)-chlorophenylalanylamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - SB-710411: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - SB-710411: 2

Experts

1.	Chen, Shuo: 1 article (01/2016)
2.	Chen, Zhi-Wu: 1 article (01/2016)
3.	Luo, Sheng-Yong: 1 article (01/2016)
4.	Qin, Yi-De: 1 article (01/2016)
5.	Liu, Dian-Gang: 1 article (11/2009)
6.	Wang, Jin: 1 article (11/2009)
7.	Wang, Yu: 1 article (11/2009)
8.	Zhang, Zhong-Tao: 1 article (11/2009)

Related Diseases

1.	Fibrosis (Cirrhosis) 11/01/2009 - "The urotension II antagonist SB-710411 arrests fibrosis in CCL4 cirrhotic rats." 01/01/2016 - "SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats. " 11/01/2009 - "In vivo, treatment with SB-710411 significantly reduced fibrosis development and down-regulated the profibrogenic cytokines TGF-β1 and TIMP-1. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2016 - "However, the effect of SB-710411 on myocardial ischemia-reperfusion (I/R) injury is unclear. "
3.	Reperfusion Injury 01/01/2016 - "Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway."
4.	Infarction (Infarctions) 01/01/2016 - "SB-710411 1.0 and 2.0 μg/kg significantly reduced cardiac I/R-induced the infarct size and histological damage in rat myocardium, markedly inhibited the changes of hemodynamic parameters and the increases of ST-segment in ECG, the serum LDH and CK-MB activities and cTnI level in rats subjected to myocardial I/R injury. "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-1
2.	Cytokines
3.	Urotensins
4.	urotensin II