|1.||Sezai, Akira: 5 articles (01/2016 - 11/2006)|
|2.||Shiono, Motomi: 5 articles (01/2016 - 11/2006)|
|3.||Tsutamoto, Takayoshi: 5 articles (12/2009 - 10/2005)|
|4.||Wakui, Shinji: 4 articles (06/2015 - 11/2006)|
|5.||Horie, Minoru: 4 articles (12/2009 - 10/2005)|
|6.||Fujii, Masanori: 4 articles (12/2009 - 10/2005)|
|7.||Yamamoto, Takashi: 4 articles (12/2009 - 10/2005)|
|8.||Yoshitake, Isamu: 3 articles (06/2015 - 01/2013)|
|9.||Sugimoto, Koichi: 3 articles (01/2015 - 12/2013)|
|10.||Saito, Tomiyoshi: 3 articles (01/2015 - 12/2013)|
08/01/2014 - "Carperitide is effective for heart failure (HF) owing to its diuretic and vasodilatory effects. "
08/01/2014 - "This recombinant peptide may also have direct cardioprotective effects because carperitide reduces the severity of heart failure and limits infarct size. "
11/01/2008 - "Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study."
11/01/2015 - "Carperitide (α-human A-type natriuretic peptide) has been used for more than one-half of all acute heart failure (AHF) patients in Japan. "
11/01/2015 - "Carperitide Is Associated With Increased In-Hospital Mortality in Acute Heart Failure: A Propensity Score-Matched Analysis."
08/01/2014 - "Because coronary vasodilation is an important cardioprotective treatment modality, we investigated whether carperitide increased coronary blood flow (CBF) and improved myocardial metabolic and contractile dysfunction during ischemia in canine hearts. "
06/01/2003 - "Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts."
11/01/1987 - "The results show that a 4-h intrarenal infusion of alpha-hANP after renal ischemia can preserve glomerular filtration rate and reduce renal tissue damage."
11/01/1987 - "After ischemia, a 4-h intrarenal infusion of alpha-hANP restored 14C-inulin clearances in bilaterally and unilaterally intact animals from 0.05 +/- 0.006 and 0.05 +/- 0.01 ml/min per 100 g to 0.314 +/- 0.04 and 0.25 +/- 0.01 ml/min per 100 g, respectively (P less than 0.001, n = 8), compared with normal values of 0.49 +/- 0.023 ml/min per 100 g. "
08/01/1989 - "Thus, the infusion of alpha-hANP markedly improved the renal function of the ischemic kidney by the reconstructive surgery of the renal artery, suggesting that alpha-hANP seems clinically applicable as a protective agent in renal ischemia at renovascular surgery as well as the renal transplantation."
09/01/2009 - "Long-term carperitide treatment attenuates ventricular remodeling and ameliorates the progression of chronic HF. "
11/01/2006 - "Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic peptide (hANP) during cardiac surgery: possibility of postoperative left ventricular remodeling effect."
09/01/2009 - "Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis."
06/01/2010 - "I/R-induced increases in serum concentrations of BUN and creatinine and urinary concentrations of NAG were also reduced by alpha-hANP, with improved histopathological changes, including acute tubular necrosis at 24-48 h after reperfusion. "
07/01/2008 - "alpha-hANP also reduced I/R-induced increases in the concentrations of blood urea nitrogen and serum creatinine, and improved histopathologic changes, including acute tubular necrosis. "
|5.||Hypertension (High Blood Pressure)
11/01/1991 - "In six patients with essential hypertension (EH) and in six healthy volunteers (C) the effects of a 60-min intravenous (iv) infusion of human atrial natriuretic peptide (alpha-hANP) (24 ng/min/kg) on systemic and renal hemodynamics and renal excretory function were evaluated. "
02/20/1990 - "After the infusion of the 0.03 micrograms/kg/min dose of alpha-hANP, systolic blood pressure fell from 115 +/- 17 mmHg to 109 +/- 15 mmHg in normal subjects, and fell significantly from 163 +/- 33 mmHg to 145 +/- 26 mmHg in patients with essential hypertension. "
12/01/1988 - "Plasma gamma-hANP(1-25)-like immunoreactivity levels were changed together with alpha-hANP-like immunoreactivity in patients with essential hypertension and adrenal disorders. "
10/01/1987 - "Renal, cardiovascular and hormonal effects of alpha-human atrial natriuretic peptide on essential hypertension."
03/01/1987 - "Patients with essential hypertension appear to have exaggerated renal responses to administered alpha-hANP, although the number of subjects studied is small and matching with normotensive controls was imperfect. "
|3.||Nicorandil (SG 75)
|8.||Adenosine Triphosphate (ATP)
|9.||Atrial Natriuretic Factor (ANF)
|10.||human NPPA protein (carperitide)
|4.||Renal Dialysis (Hemodialysis)