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bisperoxovanadium

a phosphotyrosyl phosphatase inhibitor

Also Known As:

bpV vanadium compound; pyridin-2-squaramide

Networked: 20 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Vanadium Compounds: 87
  - bisperoxovanadium: 20

Experts

1.	Walker, Chandler L: 5 articles (10/2021 - 01/2012)
2.	Xu, Xiao-Ming: 4 articles (01/2019 - 01/2012)
3.	Liu, Nai-Kui: 3 articles (01/2019 - 01/2012)
4.	Wan, Qi: 2 articles (12/2019 - 01/2017)
5.	Li, Kai: 2 articles (12/2019 - 01/2019)
6.	Liu, Jia: 2 articles (12/2019 - 01/2019)
7.	Zhou, Jing: 2 articles (12/2019 - 01/2019)
8.	Lonsway, Thomas: 1 article (10/2021)
9.	Mann, Ranjeet: 1 article (10/2021)
10.	Tierney, Lydia: 1 article (10/2021)

Related Diseases

1.	Infarction (Infarctions) 11/01/2019 - "Application of the PTEN inhibitor bisperoxovanadium (BpV) (1.0 mg/kg) reduced postischemic infarct size, attenuated cardiomyocyte apoptosis, and improved cardiac dysfunction in normal, but not in hypercholesterolemic mice. " 04/01/2010 - "Here we studied 1) whether the pharmacological inhibition of PTEN by bisperoxovanadium molecules [BpV(HOpic)] attenuates simulated I/R (SIR) injury in vitro and 2) whether the administration of BpV(HOpic) either before or after ischemia limits myocardial infarct size (IS) and ameliorates cardiodysfunction caused by infarction. "
2.	Ischemia 02/01/2019 - "The aim of this study was to investigate whether bisperoxovanadium has a potential neuroprotective effect in an ischemia/reperfusion animal model. " 04/01/2010 - "Here we studied 1) whether the pharmacological inhibition of PTEN by bisperoxovanadium molecules [BpV(HOpic)] attenuates simulated I/R (SIR) injury in vitro and 2) whether the administration of BpV(HOpic) either before or after ischemia limits myocardial infarct size (IS) and ameliorates cardiodysfunction caused by infarction. " 02/01/2019 - "[Marginal protection of retinal cells by bisperoxovanadium : Appropriate therapy in the model of retinal ischemia?]" 09/01/2014 - "One hundred and twenty-eight neonate (10 days) SD rats were divided into four groups: hypoxia-ischemia (HI), sham control (Sham), bisperoxovanadium (bpv), and normal saline (NS) group. "
3.	Myocardial Infarction 04/01/2010 - "Here we studied 1) whether the pharmacological inhibition of PTEN by bisperoxovanadium molecules [BpV(HOpic)] attenuates simulated I/R (SIR) injury in vitro and 2) whether the administration of BpV(HOpic) either before or after ischemia limits myocardial infarct size (IS) and ameliorates cardiodysfunction caused by infarction. " 01/01/2012 - "BpV(pic) and bpV(phen), two bisperoxovanadium molecules and PTEN inhibitors, may be involved in limiting myocardial infarction. "
4.	Stroke (Strokes) 01/01/2019 - "Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery. "
5.	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 12/30/2019 - "Results showed that bisperoxovanadium (pyridin-2-squaramide) attenuated not only cognitive dysfunction but also alleviated histopathological changes in rats with vascular dementia. " 12/30/2019 - "It is concluded that the novel squaramide compound bisperoxovanadium (pyridin-2-squaramide) might be effective in the treatment of vascular dementia by activation of Akt and Erk1/2." 12/30/2019 - "It has been reported that bisperoxovanadium (pyridin-2-squaramide), a novel squaramide compound, protects against cerebral ischemia injury via activation of Akt and Erk1/2. Here, the potential neuroprotective effect of bisperoxovanadium is shown for the first time in a model of vascular dementia induced in 6-month-old male Sprague-Dawley rats by two-vessel occlusion injury applied to 6-month-old. "

Related Drugs and Biologics

1.	Phosphoric Monoester Hydrolases (Phosphatases)
2.	Tensins
3.	squaramide
4.	Neuroprotective Agents
5.	oxodiperoxo(pyridine- 2- carboxylate)vanadate(V)
6.	TOR Serine-Threonine Kinases
7.	PTEN Phosphohydrolase (PTEN Phosphatase)
8.	Retinaldehyde (Retinal)
9.	Ligands
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics