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dimethylarsinous acid

a reactive organic intermediate of dimethylarsinic acid involved in toxicity
Also Known As:
dimethylarsinite
Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Naranmandura, Hua: 4 articles (09/2011 - 04/2007)
2. Suzuki, Kazuo T: 3 articles (03/2008 - 04/2007)
3. Del Razo, Luz M: 2 articles (11/2011 - 03/2005)
4. Valenzuela, Olga L: 2 articles (11/2011 - 03/2005)
5. Cohen, Samuel M: 1 article (10/2013)
6. Arnold, Lora L: 1 article (10/2013)
7. Liu, Xiangde: 1 article (10/2013)
8. Qiu, Fang: 1 article (10/2013)
9. Rennard, Stephen I: 1 article (10/2013)
10. Kakiuchi-Kiyota, Satoko: 1 article (10/2013)

Related Diseases

1. Neoplasms (Cancer)
11/01/2011 - "Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent and character of toxic and cancer-promoting effects of iAs exposure. "
03/01/2005 - "Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent and character of toxic and cancer-promoting effects of iAs exposure. "
10/04/2013 - "In this study, cytotoxicity and gene expression changes for arsenite (iAs(III)), monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) were evaluated in three human cell types, urothelial (1T1), keratinocyte (HEK001) and bronchial epithelial (HBE) cells, corresponding to target organs for iAs-induced cancer. "
03/27/2013 - "Inorganic arsenic [As(V)+As(III)] and its metabolites, especially the trivalent forms [monomethylarsonous acid, MMA(III), and dimethylarsinous acid, DMA(III)], are considered the forms of arsenic with the highest degree of toxicity, linked to certain types of cancer and other pathologies. "
03/15/2008 - "Thioarsenicals dimethylmonothioarsinic (DMMTA(V)) and dimethyldithioarsinic (DMDTA(V)) acids are common urinary metabolites, the former being much more toxic than non-thiolated dimethylarsinic acid (DMA(V)) and comparable to dimethylarsinous acid (DMAIII) in epidermoid cells, suggesting that the metabolic production of thioarsenicals may be a risk factor for the development of cancer in these organs. "
2. Hepatocellular Carcinoma (Hepatoma)
3. Urinary Bladder Neoplasms (Bladder Cancer)
4. Tetraploidy
5. Insulin Resistance

Related Drugs and Biologics

1. arsenite
2. Cacodylic Acid (Cacodylate)
3. monomethylarsonous acid
4. arsenic acid (arsenate)
5. monomethylarsonic acid (MSMA)
6. Arsenic
7. Arsenicals (Arsenic Compounds)
8. monomethylmonothioarsonic acid
9. dimethyldithioarsinic acid
10. dimethylmonothioarsinic acid