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stampidine

an anti-HIV agent; structure in first source

Also Known As:

stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate)

Networked: 8 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Uckun, Fatih M: 6 articles (04/2012 - 11/2002)
2.	Qazi, Sanjive: 3 articles (01/2020 - 11/2002)
3.	D'Cruz, Osmond J: 3 articles (02/2008 - 12/2003)
4.	Petkevich, Alexander S: 2 articles (06/2004 - 01/2004)
5.	Tibbles, Heather E: 2 articles (06/2004 - 01/2004)
6.	Titov, Leonid: 2 articles (06/2004 - 01/2004)
7.	Vassilev, Alexei O: 2 articles (06/2004 - 01/2004)
8.	Waurzyniak, Barbara: 2 articles (12/2003 - 11/2002)
9.	Elibol, Birsen: 1 article (01/2020)
10.	Kilic, Ulkan: 1 article (01/2020)

Related Diseases

1.	HIV Infections (HIV Infection) 07/01/2005 - "Several preclinical studies conducted thus far, suggest that stampidine has clinical potential as a dual-function topical agent for the prevention and/or effective treatment of oculo-genital ADV/HIV infections."
2.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "Chemopreventive efficacy of stampidine in a murine breast cancer model." 01/01/2020 - "Background: The purpose of the present study was to examine the chemopreventive effect of stampidine, an aryl phosphate derivative of stavudine, in side by side comparison with the standard anti-breast cancer drug paclitaxel in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)-induced murine breast cancer model.Methods"
3.	Carcinogenesis 01/01/2020 - "Tumors from mice treated with stampidine or stampidine plus paclitaxel displayed unique changes of a signature protein cassette comprised BRCA1, p21, Bax, and Bcl-2.Conclusion: Stampidine has potent chemopreventive activity and is as effective as the standard chemotherapy drug paclitaxel in the chemical carcinogenesis."
4.	Neoplasms (Cancer) 01/01/2020 - "The length of time for the initial tumor to appear in DMBA-challenged mice treated with stampidine was longer than that of mice treated DMBA-challenged control mice. " 01/01/2020 - ": Stampidine resulted in substantially reduced numbers of tumors, tumor weight as well as tumor size in DMBA-treated mice. " 01/01/2020 - "Stampidine was as effective as paclitaxel in the model and their combination exhibited greater chemopreventive activity, as measured by reduced tumor incidence and improved tumor-free survival as well as overall survival of DMBA-treated mice. " 01/01/2020 - "Tumors from mice treated with stampidine or stampidine plus paclitaxel displayed unique changes of a signature protein cassette comprised BRCA1, p21, Bax, and Bcl-2.Conclusion: Stampidine has potent chemopreventive activity and is as effective as the standard chemotherapy drug paclitaxel in the chemical carcinogenesis."
5.	Infections 02/01/2008 - "Extensive preclinical studies have shown that stampidine and a candidate thiourea NNRTI (HI-443) have clinical potential as a safe combination microbicide to inhibit, prevent or treat mucosal HIV-1 infections."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Proteins (Proteins, Gene)
3.	Stavudine (Zerit)
4.	Phosphates (Orthophosphate)
5.	9,10-Dimethyl-1,2-benzanthracene
6.	Thiourea
7.	Anti-Infective Agents (Microbicides)
8.	Anti-Retroviral Agents (Antiretroviral Agents)
9.	Anti-HIV Agents (AIDS Drugs)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)