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1- (2- (acridin- 9- ylamino)ethyl)- 1,3- dimethylthiourea

structure in first source

Also Known As:

1-(2-AE)-DMU; ACRAMTU

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - 1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthiourea: 4

Experts

1.	Bierbach, Ulrich: 4 articles (01/2013 - 01/2005)
2.	Hess, Suzanne M: 2 articles (10/2005 - 01/2005)
3.	Binz, Kristen L: 1 article (01/2013)
4.	Dutta, Samrat: 1 article (01/2013)
5.	Guthold, Martin: 1 article (01/2013)
6.	Roll, Eric H: 1 article (01/2013)
7.	Rosile, David: 1 article (01/2013)
8.	Snyder, Matthew J: 1 article (01/2013)
9.	Suryadi, Jimmy: 1 article (01/2013)
10.	Kucera, Gregory L: 1 article (07/2010)

Related Diseases

1.	Neoplasms (Cancer) 07/19/2010 - "In a cell proliferation assay, a significant decrease in cytotoxicity was observed for PT-ACRAMTU, when cancer cells were pretreated with netropsin, suggesting that minor-groove adducts in cellular DNA contribute to the biological activity of the hybrid agent."
2.	Lung Neoplasms (Lung Cancer) 10/01/2005 - "PT-ACRAMTU appeared to have a similar IC50 value to cisplatin except in H460 lung cancer cells in which PT-ACRAMTU had a twofold lower IC50 value. "
3.	Glioblastoma (Glioblastoma Multiforme) 01/17/2005 - "Using clonogenic survival assays, we demonstrated that a new platinum-acridine hybrid agent, PT-ACRAMTU, is cytotoxic in SNB19 and U87MG glioblastoma cells at low-micromolar concentrations. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2013 - "PT-ACRAMTU is the parent drug of a family of non-classical platinum-based agents that show potent activity in non-small cell lung cancer in vitro and in vivo. "

Related Drugs and Biologics

1.	Platinum
2.	Netropsin
3.	DNA (Deoxyribonucleic Acid)
4.	Cisplatin (Platino)
5.	Acridines