cajanol

an antifungal phytoalexin from Cajanus cajan

Also Known As:

2,3-dihydro-5-hydroxy-3-(4-hydroxy-2-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biological Toxins: 20
  - Phytoalexins: 153
    - cajanol: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        cajanol: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        cajanol: 5

Experts

1.	Fu, Yujie: 2 articles (12/2013 - 10/2010)
2.	Liang, Lu: 2 articles (12/2013 - 01/2011)
3.	Luo, Meng: 2 articles (12/2013 - 10/2010)
4.	Efferth, Thomas: 2 articles (01/2011 - 10/2010)
5.	Gong, Zheng: 1 article (01/2021)
6.	Guo, Mingqi: 1 article (01/2021)
7.	Jiang, Jing: 1 article (01/2021)
8.	Li, Peiling: 1 article (01/2021)
9.	Li, Wenle: 1 article (01/2021)
10.	Sui, Ming: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2011 - "The present study shows that cajanol possesses antibacterial activity in vitro towards both gram-negative and gram-positive bacteria and therefore may be a promising candidate as an antibacterial agent for the therapy of microbial infections."
2.	Breast Neoplasms (Breast Cancer) 10/06/2010 - "In the present study, the anticancer activity of cajanol towards MCF-7 human breast cancer cells was investigated. " 10/06/2010 - "Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway."
3.	Neoplasms (Cancer) 10/06/2010 - "To the best of our knowledge, this is the first report demonstrating the cytotoxic activity of cajanol towards cancer cells in vitro." 10/06/2010 - "As the most effective phytoalexin in pigeonpea, the cytotoxic activity of cajanol towards cancer cells has not been report as yet. " 01/01/2021 - "We found that 8 μM cajanol significantly restored the sensitivity of A2780/Taxol cells to paclitaxel, and in vivo experiments demonstrated that the combination of 0.5 mM/kg paclitaxel and 2 mM/kg cajanol significantly inhibited the growth of A2780/Taxol metastatic tumors in mice. " 01/01/2021 - "Cajanol is an isoflavone from pigeon pea (Cajanus cajan) that has been reported to have anti-tumor activity. "
4.	Prostatic Neoplasms (Prostate Cancer) 12/01/2013 - "The phytoestrogenic compound cajanol from Pigeonpea roots is associated with the activation of estrogen receptor α-dependent signaling pathway in human prostate cancer cells."
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "In this work, we evaluate the effect of cajanol in reversing paclitaxel resistance of the A2780/Taxol ovarian cancer cell line in vitro and in vivo, and we discuss its mechanism of action. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Paclitaxel (Taxol)
3.	Estrogen Receptors
4.	Isoflavones
5.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics