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11- Mrp- 14- Nal- 18- Cys- 22- Asp- beta- MSH(11- 22)NH2
a melanocortin 4 receptor antagonist
Also Known As:
JKC 363; JKC-363; JKC363; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Peptides: 82426
Neuropeptides: 6772
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Cyclic Peptides: 530
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Melanocyte-Stimulating Hormones: 1119
beta-MSH: 87
11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2: 1
Experts
1.
Abbott, Caroline R
: 1 article (06/2002)
2.
AlAhmed, Samaher H
: 1 article (06/2002)
3.
Bloom, Stephen R
: 1 article (06/2002)
4.
Kim, Min Seon
: 1 article (06/2002)
5.
Rossi, Michela
: 1 article (06/2002)
6.
Smith, David M
: 1 article (06/2002)
Related Diseases
1.
Hyperphagia (Overeating)
06/01/2002 - "
To clarify the roles of the MC3-R and MC4-R in AgRP-induced hyperphagia, the feeding effect of AgRP (83-132) was compared with that of the selective MC4-R antagonist, JKC-363 (cyclic [Mpr11, D-Nal14, Cys18, Asp22-NH2]-beta-MSH11-22).
"
2.
Body Weight (Weight, Body)
06/01/2002 - "
An increase in body weight at 24 and 48 h was observed following AgRP (83-132) but not JKC-363 treatment.
"