|1.||Mor, Gil: 10 articles (05/2011 - 05/2003)|
|2.||Alvero, Ayesha B: 8 articles (04/2009 - 01/2004)|
|3.||Brown, David: 7 articles (03/2012 - 05/2003)|
|4.||Morré, Dorothy M: 6 articles (08/2011 - 01/2005)|
|5.||Morré, D James: 5 articles (08/2011 - 01/2005)|
|6.||Rutherford, Thomas: 4 articles (08/2008 - 05/2003)|
|7.||Howes, Laurence G: 3 articles (01/2011 - 10/2006)|
|8.||de Souza, Paul L: 3 articles (01/2011 - 10/2006)|
|9.||Brown, David M: 3 articles (08/2010 - 07/2005)|
|10.||Kelly, Graham: 3 articles (05/2009 - 02/2006)|
|1.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2008 - "In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells."
06/01/2006 - "In this review, the current understanding of the mechanism of action of phenoxodiol, its potential clinical application for the treatment of ovarian cancer and the concept of chemosensitization are discussed."
06/01/2006 - "Phenoxodiol, a novel approach for the treatment of ovarian cancer."
04/01/2004 - "Phenoxodiol offers hope for ovarian cancer."
05/01/2003 - "Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells."
|2.||Prostatic Neoplasms (Prostate Cancer)
08/01/2010 - "Although a precise target for Phenoxodiol has not been identified, these data contribute to our understanding of the mechanism by which this drug promotes cell death in prostate cancer cells, and warrants the continued clinical development of Phenoxodiol as a therapeutic for the treatment of metastatic prostate cancer."
08/01/2010 - "In this study we tested the effects of Phenoxodiol against prostate cancer cell lines. "
01/01/2014 - "Phenoxodiol demonstrates an ability in prostate cancer cells to induce significant cytotoxicity in cells by interacting with p21(WAF1) and inducing cell cycle arrest irrespective of p53 status or caspase pathway interactions. "
01/01/2014 - "Three prostate cancer cell lines-LNCaP, DU145, and PC3 were cultured in vitro, and then treated with phenoxodiol (10 μM and 30 μM) for 24 and 48 h. "
01/01/2014 - "The effects of phenoxodiol on the cell cycle of prostate cancer cell lines."
08/01/2010 - "An in vivo model confirmed the potential therapeutic efficacy of Phenoxodiol when administered orally to tumor bearing mice. "
01/01/2012 - "The cellular potency of compounds 7e and 12h were found to have greater in vitro inhibitory activities than phenoxodiol, the parental compound currently in late-stage clinical trials for the treatment of cancer. "
01/01/2011 - "This study reports the pharmacokinetics of phenoxodiol in patients with cancer. "
01/01/2011 - "Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. "
02/24/2009 - "Phenoxodiol is a novel isoflav-3-ene, currently undergoing clinical trials, that has a broad in vitro activity against a number of human cancer cell lines. "
|4.||Neoplasm Metastasis (Metastasis)
07/08/2005 - "An in vitro coculture model of prostate cancer cells (LNCaP) with human osteoblasts (hFOB) was utilized to define the efficacy of the tNOX inhibitors EGCg, capsaicin, Capsibiol-T and phenoxodiol against bone metastasis of prostate cancer alone and in combination with Taxol and cisplatin. "
|5.||Melanoma (Melanoma, Malignant)
11/01/2006 - "We found that induction of apoptosis by Phenoxodiol was maximal at 48 h with a range of apoptosis of 12+/-4 to 48+/-5% in different melanoma lines. "
01/01/2007 - "Phenoxodiol can sensitize melanoma cells to Carboplatin in vitro with corresponding XIAP degradation, although the precise target and mechanism of action of Phenoxodiol are subject to further assessment. "
11/01/2006 - "Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells."
11/01/2006 - "Together, these studies suggest that Phenoxodiol induces apoptosis of melanoma cells by induction of p53-dependent BH3 proteins (Bad, PUMA and Noxa) and the p53-independent Bim protein, resulting in activation of Bax and its downstream events."
01/01/2007 - "The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization."
|1.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)