HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ZK 191784

structure in first source

Also Known As:

(5Z,7E,22E)-(1S,3R,24R)-25-(5-butyloxazole-2-yl)-26,27-cyclo-9,10-secocholesta-5,7,10(19)22-tetraene-1,3,24-triol; ZK-191784; ZK191784

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Steinmeyer, Andreas: 5 articles (12/2011 - 12/2002)
2.	Zuegel, Ulrich: 2 articles (12/2011 - 04/2009)
3.	Zügel, Ulrich: 2 articles (10/2006 - 12/2002)
4.	Martinesi, Maria: 1 article (12/2011)
5.	Nesi, Gabriella: 1 article (12/2011)
6.	Santi, Raffaella: 1 article (12/2011)
7.	Simoni, Antonella: 1 article (12/2011)
8.	Stio, Maria: 1 article (12/2011)
9.	Treves, Cristina: 1 article (12/2011)
10.	Haberland, Michael: 1 article (04/2009)

Related Diseases

1.	Colitis 12/28/2007 - "The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs." 12/28/2007 - "Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. " 12/28/2007 - "Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype."
2.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2006 - "ZK191784 enhanced bone TRPV6 mRNA levels and 1,25(OH)2D3 as well as ZK191784 stimulated secretion of the bone formation marker osteocalcin in rat osteosarcoma cells, albeit to a different extent. "
3.	Prostatic Neoplasms (Prostate Cancer) 12/01/2011 - "The novel vitamin D analog ZK191784 inhibits prostate cancer cell invasion."
4.	Inflammation (Inflammations) 12/28/2007 - "Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. "
5.	Immune System Diseases (Immune Disorders) 12/01/2002 - "ZK 191784 is the first representative of a novel class of vitamin D analogs that might have therapeutic potential in T cell-mediated immune disorders."

Related Drugs and Biologics

1.	Calcitriol (Calcijex)
2.	Dextrans (Dextran)
3.	sodium sulfate (sodium bisulfate)
4.	Vitamin D
5.	Calcitriol Receptors (Calcitriol Receptor)
6.	Interleukin-10 (Interleukin 10)
7.	Apolipoprotein A-I (Apolipoprotein A1)
8.	Osteocalcin
9.	Transcription Factors (Transcription Factor)
10.	Messenger RNA (mRNA)