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pedilstatin

from a republic of maldives Pedilanthus sp.; structure in first source

Also Known As:

13-O-acetyl-12-O-(2'Z,4'E-octadienoyl)-4alpha-deoxyphorbol

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Phorbols: 26
        pedilstatin: 1

Experts

1.	Blumberg, Peter M: 1 article (09/2002)
2.	Boyd, Michael R: 1 article (09/2002)
3.	Doubek, Dennis L: 1 article (09/2002)
4.	Ducki, Sylvie: 1 article (09/2002)
5.	Gardella, Roberta S: 1 article (09/2002)
6.	Lewin, Nancy E: 1 article (09/2002)
7.	McMahon, James B: 1 article (09/2002)
8.	Pettit, George R: 1 article (09/2002)
9.	Tackett, Larry P: 1 article (09/2002)
10.	Tan, Rui: 1 article (09/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2002 - "A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-O-acetyl-12-O-[2'Z,4'E-octadienoyl]-4alpha-deoxyphorbol on the basis of high-resolution mass spectral and 2D NMR assignments. "
2.	Lymphoid Leukemia 09/01/2002 - "Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED(50) of 0.28 microg/mL, to afford, at concentrations of 2-5 microM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K(i) of 620 +/- 20 nM."
3.	Infections 09/01/2002 - "Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED(50) of 0.28 microg/mL, to afford, at concentrations of 2-5 microM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K(i) of 620 +/- 20 nM."

Related Drugs and Biologics

1.	Protein Kinase C
2.	Growth Inhibitors