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4,8- dimethoxy- 7- hydroxyfuro(2,3- b)quinoline

from callus of Haplophyllum patavinum (Rutaceae); structure in first source

Also Known As:

haplopine

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline: 3
  - 3-Ring Heterocyclic Compounds
    - 4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline: 3

Experts

1.	Choi, Han-Seok: 1 article (05/2021)
2.	Jegal, Jonghwan: 1 article (05/2021)
3.	Jo, Beom-Geun: 1 article (05/2021)
4.	Kim, Tae-Young: 1 article (05/2021)
5.	Kim, Ye Jin: 1 article (05/2021)
6.	Yang, Min Hye: 1 article (05/2021)
7.	Abe, Masahiko: 1 article (07/2017)
8.	Akihisa, Toshihiro: 1 article (07/2017)
9.	Kikuchi, Takashi: 1 article (07/2017)
10.	Koike, Kazuo: 1 article (07/2017)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 05/19/2021 - "Haplopine Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and TNF-α/IFN-γ-Induced Inflammation in Human Keratinocyte." 05/19/2021 - "This study aimed to investigate the anti-inflammatory, antioxidant, and anti-atopic dermatitis (AD) effects of haplopine, which is one of the active components in D. "
2.	Inflammation (Inflammations) 05/19/2021 - "Haplopine Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and TNF-α/IFN-γ-Induced Inflammation in Human Keratinocyte."
3.	Experimental Melanoma 07/01/2017 - "Upon evaluation of compounds 1 - 13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-1-methylquinolin-2(1H)-one (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells. "
4.	Malaria 10/01/2023 - "Overall, this computational approach suggests that these haplopine derivatives could serve as a potential source for developing new, effective antimalarial drugs to combat malaria. " 10/01/2023 - "Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach."
5.	Dermatitis 05/19/2021 - "In vivo, haplopine significantly attenuated the development of AD symptoms in 2,4-dinitrochlorobenzene (DNCB)-stimulated Balb/c mice, as evidenced by reduced clinical dermatitis scores, skin thickness measurements, mast cell infiltration, and serum IgE concentrations. "

Related Drugs and Biologics

1.	Antioxidants
2.	Melanocyte-Stimulating Hormones (MSH)
3.	Immunoglobulin E (IgE)
4.	Dinitrochlorobenzene (DNCB)
5.	Antimalarials (Antimalarial Agents)
6.	limonin