Ribonuclease 7

an innate immune defense antimicrobial protein of healthy human skin; amino acid sequence in first source; do not confuse with SAP2 protein, from Candida; RefSeq NM_032572

Also Known As:

RNASE7 protein, human; RNase 7; RNase 7 protein, human; RNase-7; RNase7; SAP-2 protein, human; SAP2 protein, human; Skin-derived antimicrobial protein 2, human; ribonuclease, RNase A family, 7 protein, human

Networked: 51 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        Ribonuclease 7: 51

Experts

1.	Harder, Jürgen: 13 articles (07/2021 - 05/2010)
2.	Gläser, Regine: 7 articles (07/2021 - 05/2010)
3.	Hains, David S: 6 articles (11/2021 - 07/2011)
4.	Becknell, Brian: 6 articles (01/2019 - 01/2015)
5.	Spencer, John David: 6 articles (01/2019 - 04/2013)
6.	Schwaderer, Andrew L: 5 articles (11/2021 - 07/2011)
7.	Rademacher, Franziska: 5 articles (07/2021 - 01/2013)
8.	Eichler, Tad: 4 articles (11/2021 - 04/2013)
9.	Spencer, John D: 4 articles (11/2021 - 07/2011)
10.	Li, Birong: 4 articles (01/2019 - 01/2015)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 11/15/2021 - "Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections." 01/01/2019 - "To investigate RNase 7's role in preventing urinary tract infection (UTI), we quantified urinary RNase 7 concentrations in 29 girls and adolescents with a UTI history and 29 healthy female human controls. " 05/05/2022 - "These results will help clarify the correlation between AMP production and UTI, identify the relationship between urinary tract infection and diabetes in UTI patients, and develop novel diagnostics or possible treatments targeting RNase 7." 09/01/2017 - "Urine concentrations of human beta-defensins and ribonuclease 7 in urinary tract infection and asymptomatic bacteriuria." 11/15/2021 - "Ribonuclease 7 (RNase 7) is an antimicrobial peptide that prevents urinary tract infections (UTI); however, it is yet unknown how RNASE7 genetic variations affect its antimicrobial activity and its mitigation of UTI risk. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2017 - "Activated T cells in lesional skin of patients with atopic dermatitis (AD) and psoriasis (PSO) might be directly exposed to RNase 7. In addition to their antimicrobial activity, immunoregulatory functions have been published for several AMPs. " 01/01/2013 - "This combination was more effective in inducing RNase 7 than the combination of IL-17A/TNF-α, a combination previously identified as a strong inducer of psoriasis-related immune response genes including several AMP. " 05/01/2010 - "Accordingly, induced in vivo secretion of RNase 7, psoriasin, and hBD-2 was detected using ELISA on lesional skin in AD and in even higher concentrations in psoriasis. " 01/01/2018 - "Ribonuclease (RNase) 7 is one of the major antimicrobial peptides secreted by keratinocytes and is expressed in significantly higher amounts in lesional skin of patients with atopic dermatitis or psoriasis than in healthy individuals. " 11/01/2017 - "The antimicrobial peptide (AMP) RNase 7 is constitutively expressed in the epidermis of healthy human skin and has been found to be upregulated in chronic inflammatory skin diseases such as atopic dermatitis and psoriasis. "
3.	Cystitis 05/05/2022 - "RNase 7 may be an anti-inflammatory and anti-infective mediator in bladder cells by downregulating the JAK/STAT signaling pathway and may be beneficial in treating cystitis in DM patients. "
4.	Communicable Diseases (Infectious Diseases) 03/22/2016 - "In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases. "
5.	Infections 11/15/2021 - "Wild-type RNase 7 overexpression in human urothelial cultures reduced UPEC invasive infection compared with mutant overexpression. " 01/01/2020 - "Due RNase 7 has antimicrobial activity, its downregulation can make prone to DM2 patients to develop infections and impaired wound healing." 01/01/2019 - "Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection." 01/01/2018 - "Intracellular analysis by flow cytometry demonstrated that the highest levels of RNase 7 were observed 6 h post-infection and the induction was dependent on direct interaction between airway epithelial cells and Mtb. " 01/01/2018 - "Our data indicate that RNase 7 exhibits potent immunomodulatory functions and supports the efficient recognition of microbial infections by human skin-infiltrating pDCs."

Related Drugs and Biologics

1.	Ribonucleases (Ribonuclease)
2.	Adenosine Monophosphate (AMP)
3.	Proteins (Proteins, Gene)
4.	Anti-Bacterial Agents (Antibiotics)
5.	S100 Calcium Binding Protein A7
6.	beta-Defensins
7.	Peptides (Polypeptides)
8.	Hepcidins
9.	S100 Proteins (S 100 Protein)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics