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diosgenone

RN given for (25R)-isomer; isolated from Solanum nudum; structure in first source

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - diosgenone: 6
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - diosgenone: 6
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - diosgenone: 6

Experts

1.	Blair, Silvia: 3 articles (03/2013 - 10/2004)
2.	Pabón, Adriana: 2 articles (03/2013 - 10/2004)
3.	He, Yun: 1 article (01/2020)
4.	Lang, Bayi: 1 article (01/2020)
5.	Li, Liangqun: 1 article (01/2020)
6.	Liu, Aizhong: 1 article (01/2020)
7.	Shaowu Meng, Manfred: 1 article (01/2020)
8.	Xie, Yuying: 1 article (01/2020)
9.	Yang, Lixin: 1 article (01/2020)
10.	Zhao, Yanqiang: 1 article (01/2020)

Related Diseases

1.	Malaria 01/01/2020 - "Diosgenone [(20S,22R,25R)-spirost-4-en-3-one, C27H40O3] has been considered as a potential therapeutic alternative remedy for malaria. " 10/01/2004 - "These results are significant since diosgenone could be a new therapeutic alternative for the treatment of malaria." 08/01/2012 - "Diosgenone [(20S,22R,25R)-spirost-4-en-3-one, C(27)H(40)O(3)] has been proposed as a new therapeutic alternative for the treatment of malaria. " 01/01/2001 - "These changes were also observed when the mice were treated with methane and hexane extracts from Solanum nudum; however necrosis of hepatocytes in mice infected with malaria decreased 47-65% when they were administered either with aqueous extract, or tumacoside A and degraded diosgenone, compounds from methane and hexane extracts of Solanum nudum respectively."
2.	Parasitemia 03/14/2013 - "Malarial parasitemia in mice became reduced by oral administration of two diosgenone derivatives."
3.	Necrosis 01/01/2001 - "These changes were also observed when the mice were treated with methane and hexane extracts from Solanum nudum; however necrosis of hepatocytes in mice infected with malaria decreased 47-65% when they were administered either with aqueous extract, or tumacoside A and degraded diosgenone, compounds from methane and hexane extracts of Solanum nudum respectively."
4.	Hemolysis 08/01/2009 - "In contrast, diosgenone and SN1 did not inhibit solute-induced haemolysis. " 08/01/2009 - "However, transmission electron microscopy revealed no effect on the morphology of uninfected erythrocytes treated with either SN2 or diosgenone and neither SN induced haemolysis of uninfected erythrocytes. "

Related Drugs and Biologics

1.	Hexanes
2.	C 27 (C-27)

Related Therapies and Procedures

1.	Oral Administration