HLA-B*46:01 antigen

Also Known As:

HLA B*4601; HLA-B*4601

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7
      - Histocompatibility Antigens Class I: 1944
        HLA-B Antigens: 1869
        HLA-B*46:01 antigen: 7

Experts

1.	Baranov, V S: 1 article (01/2021)
2.	Chernov, A N: 1 article (01/2021)
3.	Glotov, O S: 1 article (01/2021)
4.	Scherbak, S G: 1 article (01/2021)
5.	Kozaru, Takeshi: 1 article (01/2018)
6.	Nagata, Kiyoshi: 1 article (01/2018)
7.	Nibuya, Masashi: 1 article (01/2018)
8.	Sakurada, Kumi: 1 article (01/2018)
9.	Suzuki, Eiji: 1 article (01/2018)
10.	Yamada, Kazuo: 1 article (01/2018)

Related Diseases

1.	Severe Acute Respiratory Syndrome 08/01/2004 - "Insights into the pathogenesis of severe acute respiratory syndrome have been made: one study suggests that human leukocyte antigen HLA-B*4601 is a possible risk factor for more severe disease, while another identifies angiotensin-converting enzyme 2 as a cellular receptor for severe acute respiratory syndrome-associated coronavirus. "
2.	Hypersensitivity (Allergy) 01/01/2018 - "Thus, the association between the HLA-B4601 allele and allergic reactions to VPA, aromatic psychotropic drugs, and CBZ should be further examined in future studies." 01/01/2018 - "Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B4601 allele."
3.	Infections 09/12/2003 - "These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. " 09/12/2003 - "At first, when analyzing infected SARS patients and high risk health care workers groups, HLA-B4601 (OR = 2.08, P = 0.04, Pc = n.s.) and HLA-B5401 (OR = 5.44, P = 0.02, Pc = n.s.) appeared as the most probable elements that may be favoring SARS coronavirus infection. " 01/01/2021 - "It has now been shown that the transmissibility and severity of COVID-19 infection can be affected by gene variants in both the human body (ACE2, HLA-B*4601, FcγRIIA, MBL, TMPRSS2, TNFA, IL6, blood group A antigen, etc.) and the virus itself (ORF8 in RNA polymerase, ORF6 in RNA primase, S, N, E proteins). "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 06/01/2004 - "A comparison of the psoriasis patients and the control group revealed that MICA010 and MICA017 were associated with Type I psoriasis whereas only MICA010 was associated with Type II. The haplotype analysis revealed that MICA008-HLA-B13-Cw0602 and MICA010-HLA-B4601-Cw01 were significantly increased in both Types I and II, whereas MICA002-HLA-B38-Cw07 (01-03) and MICA017-HLA-B57-Cw0602 were elevated only in Type I. MICA010 was in strong linkage with Cw*01. "
5.	Neoplasms (Cancer) 02/15/2003 - "Mutated p53 gene encodes a nonmutated epitope recognized by HLA-B*4601-restricted and tumor cell-reactive CTLs at tumor site."

Related Drugs and Biologics

1.	Psychotropic Drugs (Psychoactive Drugs)
2.	HLA Antigens (Human Leukocyte Antigens)
3.	Angiotensin-Converting Enzyme 2
4.	HLA-B Antigens (HLA-B)
5.	DNA Primase (Primase)
6.	Interleukin-6 (Interleukin 6)
7.	Valproic Acid (Depakote)
8.	DNA-Directed RNA Polymerases (RNA Polymerase)
9.	RNA (Ribonucleic Acid)
10.	Proteins (Proteins, Gene)