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nigerloxin

an inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity

Also Known As:

2-amido-3-hydroxy-6-methoxy-5-methyl-4-(prop-1'-enyl) benzoic acid

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        nigerloxin: 3
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Propane: 265
        nigerloxin: 3
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - nigerloxin: 3

Experts

1.	Srinivasan, Krishnapura: 3 articles (09/2014 - 04/2012)
2.	Suresha, Bharathinagar S: 3 articles (09/2014 - 04/2012)
3.	Sattur, Avinash P: 1 article (04/2012)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 09/01/2014 - "Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats." 09/01/2014 - "Thus, the results indicated the beneficial influence of nigerloxin on polyol pathway and oxidative stress associated with diabetes, which are implicated in ameliorating the development of diabetic nephropathy. "
2.	Cataract (Cataracts) 10/01/2013 - "In the present study, the beneficial influence of nigerloxin was investigated in galactose-induced cataract in experimental animals. " 10/01/2013 - "The results suggest that alteration in polyol pathway and antioxidant defense system were countered by nigerloxin in the lens of galactose-fed animals, suggesting the potential of nigerloxin in ameliorating the development of galactose-induced cataract in experimental animals." 04/01/2012 - "The results suggest the beneficial countering of polyol pathway enzymes and potentiation of the antioxidant defense system by nigerloxin in diabetic animals, implicating its potential in ameliorating cataracts in diabetics."
3.	Body Weight (Weight, Body) 09/01/2014 - "Groups of rats were orally administered with nigerloxin for 8 days (25 mg or 100 mg kg(-1) body weight day(-1)) along with gentamicin (80 mg/kg, i.p., for 8 days). " 10/01/2013 - "Groups of galactose-fed rats were orally administered with nigerloxin (25 and 100 mg/kg body weight/day) for 24 days. " 10/01/2013 - "Oral administration of nigerloxin once a day for 24 days at a dose of 100 mg/kg body weight, significantly decreased lens lipid peroxides and advanced glycation end products in galactose-fed rats. "

Related Drugs and Biologics

1.	Gentamicins (Gentamicin)
2.	Galactose (Galactopyranose)
3.	polyol
4.	Antioxidants
5.	Advanced Glycation End Products
6.	Lipid Peroxides
7.	Enzymes

Related Therapies and Procedures

1.	Oral Administration