|1.||Simões, M F: 1 article (09/2009)|
|2.||Pereira, G: 1 article (09/2009)|
|3.||Gonçalves, J: 1 article (09/2009)|
|4.||Coutinho, I: 1 article (09/2009)|
|5.||Saraiva, L: 1 article (09/2009)|
|6.||Côrte-Real, M: 1 article (09/2009)|
|7.||Marques, Cristina Gaspar: 1 article (09/2002)|
|8.||Pinto, Madalena M M: 1 article (09/2002)|
|9.||Pedro, Madalena: 1 article (09/2002)|
|10.||Nascimento, Maria São José: 1 article (09/2002)|
09/01/2009 - "6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U) is a diterpene compound isolated from Plectranthus grandidentatus with an antiproliferative effect on several human cancer cell lines. "
09/01/2009 - "Indeed, since coleon U has no effect on cPKCs and aPKC, recognised as anti-apoptotic proteins, and selectively induces an apoptotic pathway dependent on nPKC-delta and -epsilon activation, it represents a promising compound for evaluation as an anti-cancer drug."
09/01/2002 - "Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. "
|1.||Apoptosis Regulatory Proteins
|7.||calcium-independent protein kinase C