MOL 294

Also Known As:

MOL294; methyl-(4R)-4-hydroxy-4-((5S,8S)-8-methyl-1,2-dioxo-2-phenyl-2,3,5,8-tetrahydro-1H-(1,2,4)triazolo(1,2a)pyridazin-5-yl)-2-butynoate; methyl-(4S)-4-hydroxy-4-((5S,8R)-8-methyl-1,2-dioxo-2-phenyl-2,3,5,8-tetrahydro-1H-(1,2,4)triazolo(1,2a)pyridazin-5-yl)-2-butynoate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - MOL 294: 1
  - Pyridazines: 11
    - MOL 294: 1

Experts

1.	Chi, Emil Y: 1 article (11/2002)
2.	Henderson, William R: 1 article (11/2002)
3.	Kahn, Michael: 1 article (11/2002)
4.	Nguyen, Cu: 1 article (11/2002)
5.	Teo, Jia-Ling: 1 article (11/2002)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2002 - "We examined the effect of the small molecule inhibitor of redox-regulated NF-kappaB and AP-1 transcription, MOL 294 on airway inflammation and airway hyperreactivity (AHR) in a mouse model of asthma. "
2.	Eosinophilia 11/01/2002 - "MOL 294 reduced eosinophil, IL-13, and eotaxin levels in bronchoalveolar lavage fluid and airway tissue eosinophilia and mucus hypersecretion. "
3.	Asthma (Bronchial Asthma) 11/01/2002 - "We examined the effect of the small molecule inhibitor of redox-regulated NF-kappaB and AP-1 transcription, MOL 294 on airway inflammation and airway hyperreactivity (AHR) in a mouse model of asthma. "

Related Drugs and Biologics

1.	Transcription Factor AP-1 (Transcription Factor AP 1)
2.	Interleukin-13
3.	NF-kappa B (NF-kB)