isobavachalcone

09/07/2021 - "Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease."
10/01/2017 - "These results indicate that the studied flavonoids especially isobavachalcone are potential anti-inflammatory natural products that may have the potential to be developed as therapeutic agents against inflammatory conditions and even Alzheimer's disease."

01/01/2019 - "Our data demonstrated that Psoralen, Isopsoralen, and Isobavachalcone decreased intracellular content of triglyceride while all five PC compounds improved hepatocellular total cholesterol accumulation and hepatocyte damage in palmitic acid-induced primary hepatocyte model of non alcoholic fatty liver disease. "

06/01/2023 - "Isobavachalcone ameliorates the progression of osteoarthritis by suppressing NF-κB signaling pathway."

01/01/2020 - "Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway."

10/11/2022 - "However, no study has examined the effects of isobavachalcone (IBC) on the programmed cell death (PCD) of human triple-negative breast MDA-MB-231 cancer cells. "
08/28/2010 - "Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells."
01/01/2018 - "Oral administration of isobavachalcone suppresses subcutaneous HL60 xenograft tumor growth without obvious toxicity. "
07/30/2021 - "It was concluded that isobavachalcone interfered both with the lipid phase of cellular membrane and with ABCB1 transporter, and for this reason, its activity in MDR cancer cells was presumptively beneficial."
09/01/2017 - "Isobavachalcone (2',4',4-trihydroxy-3'-[3'-methylbut-3'-ethyl] chalcone or IBC) exhibits anticancer activities in a number of types of cancer cell. "