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23-hydroxybetulinic acid

structure in first source

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 23-hydroxybetulinic acid: 8

Experts

1.	Ye, Wencai: 4 articles (12/2015 - 01/2007)
2.	Wang, Guangji: 3 articles (12/2015 - 01/2007)
3.	Wu, Xiaolan: 3 articles (12/2015 - 01/2007)
4.	Zheng, Yuanting: 3 articles (12/2015 - 01/2007)
5.	Liu, Jie: 2 articles (11/2019 - 10/2015)
6.	Xu, Jinyi: 2 articles (11/2019 - 10/2015)
7.	Zhang, Hengyuan: 2 articles (11/2019 - 10/2015)
8.	Hao, Gang: 2 articles (12/2015 - 04/2010)
9.	Zhang, Jingwei: 2 articles (12/2015 - 04/2010)
10.	Zhou, Fang: 2 articles (12/2015 - 04/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2015 - "Most of the newly synthesized compounds exhibited more potent antiproliferative activity than patent compound 23-hydroxybetulinic acid, especially 13e and 14a were about four- to sevenfold more potent against all tested cancer cell lines than 23-hydroxybetulinic acid. " 11/15/2019 - "A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). " 04/21/2010 - "23-Hydroxybetulinic acid showed a synergistic cytotoxic effect on multiple cancer cell lines by combined use with doxorubicin. " 04/21/2010 - "The effect of combination treatment with 23-hydroxybetulinic acid and doxorubicin was evaluated with a quantitative combination index method based on the median-effect analysis in various cancer cell lines. " 11/22/2002 - "Our data suggest that 23-hydroxybetulinic acid may be a potential cytotoxic agent for treatment of cancer."
2.	Colonic Neoplasms (Colon Cancer) 01/01/2007 - "Quantitative analysis of 23-hydroxybetulinic acid, a novel anticancer substance, in the cellular environment of a human colon adenocarcinoma cell line for cellular pharmacokinetic studies."
3.	Cardiotoxicity 12/01/2015 - "23-Hydroxybetulinic acid (23-HBA), isolated from Pulsatilla chinensis, enhances the anticancer effect of doxorubicin while simultaneously reducing its cardiac toxicity, but does not affect the concentration of doxorubicin in the plasma and heart. " 12/01/2015 - "Protective effect of 23-hydroxybetulinic acid on doxorubicin-induced cardiotoxicity: a correlation with the inhibition of carbonyl reductase-mediated metabolism."
4.	Carcinogenesis 10/01/2022 - "23-hydroxybetulinic acid reduces tumorigenesis, metastasis and immunosuppression in a mouse model of hepatocellular carcinoma via disruption of the MAPK signaling pathway."
5.	Neoplasm Metastasis (Metastasis) 10/01/2022 - "23-hydroxybetulinic acid reduces tumorigenesis, metastasis and immunosuppression in a mouse model of hepatocellular carcinoma via disruption of the MAPK signaling pathway."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Betulinic Acid
3.	Telomerase (Telomerase Reverse Transcriptase)
4.	Cytotoxins (Cytolysins)
5.	Alcohol Oxidoreductases
6.	3-oxo-23-hydroxybetulinic acid
7.	lupeol
8.	betulin