|1.||Glick, Gary D: 11 articles (01/2010 - 10/2002)|
|2.||Opipari, Anthony W: 11 articles (01/2010 - 10/2002)|
|3.||Boitano, Anthony E: 4 articles (10/2009 - 07/2004)|
|4.||Blatt, Neal B: 4 articles (10/2009 - 10/2002)|
|5.||Ellman, Jonathan A: 4 articles (10/2003 - 10/2002)|
|6.||Lyssiotis, Costas A: 3 articles (10/2009 - 07/2004)|
|7.||Bednarski, Jeffrey J: 3 articles (07/2004 - 10/2002)|
|8.||Boitano, Anthony: 3 articles (10/2003 - 10/2002)|
|9.||Leonetti, Francesco: 3 articles (10/2003 - 10/2002)|
|10.||Cleary, Joanne: 2 articles (01/2010 - 06/2006)|
|1.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/15/2003 - "Previous work has shown that Bz-423 ameliorates disease in animal models of systemic lupus erythematosus that also have features of lymphoproliferative disease. "
07/09/2004 - "In NZB/W lupus-prone mice, Bz-423 specifically kills germinal center B cells, which are the cells that drive disease both in this model and in human systemic lupus erythematosus. "
10/06/2003 - "Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. "
04/01/2005 - "The present study demonstrates that treating human skin in organ culture with Bz-423 suppresses retinoid-induced epidermal hyperplasia. "
04/01/2005 - "Together, these data suggest that Bz-423 has the potential to limit the untoward effects associated with topical retinoid treatment, and in addition, may have therapeutic effects against other forms of epidermal hyperplasia."
04/01/2005 - "Bz-423 suppresses hyperplasia in organ culture at concentrations that also inhibit keratinocyte proliferation in monolayer culture but that are not cytotoxic for keratinocytes and do not inhibit fibroblast growth. "
03/01/2008 - "In the present study, we demonstrate that Bz-423 (formulated for topical delivery) reduces epidermal hyperplasia in human psoriatic skin after transplantation to severe, combined immunodeficient (scid) mice. "
03/01/2008 - "Bz-423 also suppresses the hyperplasia that develops in nonpsoriatic human skin as a consequence of transplantation to scid mice. "
|4.||Autoimmune Diseases (Autoimmune Disease)
03/01/2003 - "The present study was undertaken to investigate a novel 1,4-benzodiazepine (Bz-423) that induces apoptosis and limits autoimmune disease in NZB/NZW mice, to determine its activity against lupus-like disease associated with defective Fas expression. "
03/01/2003 - "Administration of Bz-423 to MRL-lpr mice significantly reduced autoimmune disease including glomerulonephritis and arthritis. "
11/01/1998 - "Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action."
09/01/1996 - "1. The behavioural and anticonvulsant effects of 10 1,4-benzodiazepine derivatives were studied after intraperitoneal administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures. "
09/01/1997 - "The anticonvulsant properties of several 1,4-benzodiazepine and azirino[1,2-d][1,4]benzodiazepine (ABDZ) derivatives were studied after intraperitoneal (IP) administration in DBA/2 mice (a strain genetically susceptible to sound-induced seizures) and in Swiss mice. "
05/01/1996 - "We evaluated whether tolerance to the antagonism of bicuculine-induced seizures by diazepam is associated with changes (i) in the content of mRNAs encoding for gamma-aminobutyric acidA (GABAA) receptor subunits, (ii) in the expression density of these subunits, and (iii) in the 1,4-benzodiazepine binding site characteristics in discrete neocortical structures. "
|6.||Morphine (MS Contin)
|8.||Hypnotics and Sedatives (Sedatives)
|9.||Proton-Translocating ATPases (ATPase, H+)
|1.||Transplantation (Transplant Recipients)