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3- carboxy- 4- methyl- 5- propyl- 2- furanpropanoic acid

a uremic toxin

Also Known As:

3-carboxy-4-methyl-5-propyl-2-furan-propionic acid; CMPF cpd

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid: 15
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Propionates: 988
      - 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid: 15
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Propionates: 988
      - 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid: 15

Experts

1.	Ando, Tadasuke: 2 articles (05/2022 - 05/2020)
2.	Itoh, Hiroki: 2 articles (05/2022 - 05/2020)
3.	Mimata, Hiromitsu: 2 articles (05/2022 - 05/2020)
4.	Ohno, Keiko: 2 articles (05/2022 - 05/2020)
5.	Ono, Hiroyuki: 2 articles (05/2022 - 05/2020)
6.	Shin, Toshitaka: 2 articles (05/2022 - 05/2020)
7.	Suzuki, Yosuke: 2 articles (05/2022 - 05/2020)
8.	Tanaka, Ryota: 2 articles (05/2022 - 05/2020)
9.	Chen, Peihong: 2 articles (05/2019 - 01/2017)
10.	Jin, Hua: 2 articles (05/2019 - 01/2017)

Related Diseases

1.	Chronic Kidney Failure (Chronic Renal Failure) 06/01/1996 - "The furan dicarboxylic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (5-propyl FPA) accumulates in the plasma of patients with chronic renal failure and is a major contributor to the drug binding defect of uraemic plasma. " 03/01/1996 - "The furan dicarboxylic acid 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (5-propyl FPA) accumulates in the plasma of patients with chronic renal failure and has been implicated in several aspects of the uremic syndrome: the defective binding of organic acids in uremic plasma, inhibition of active tubular secretion, anemia and the severity of neurological symptoms. " 11/01/2002 - "The aim of this study was to understand the mechanisms that underlie the renal elimination of albumin-bound uremic toxins, particularly the highly bound furan acid 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), that accumulate in chronic renal failure. " 04/01/2002 - "The ability of albumin to bind drugs and other lipophilic organic acids is decreased in chronic renal failure by the accumulation of albumin-bound uraemic toxins such as hippuric acid, indoxyl sulphate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF). "
2.	Gestational Diabetes (Gestational Diabetes Mellitus) 01/01/2017 - "Several recent clinical studies have suggested that the levels of circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are significantly higher in patients with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). " 05/01/2021 - "Predictive role of altered leptin, adiponectin and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid secretion in gestational diabetes mellitus."
3.	Type 2 Diabetes Mellitus (MODY) 01/01/2017 - "Several recent clinical studies have suggested that the levels of circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are significantly higher in patients with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). " 10/01/2017 - "A major metabolite of furan fatty acids, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), has been reported to be increased in patients who progress from prediabetes to type 2 diabetes, although CMPF is not necessarily associated with impaired glucose metabolism. "
4.	Glucose Intolerance 01/01/2017 - "Several recent clinical studies have suggested that the levels of circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are significantly higher in patients with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). "
5.	Fatty Liver 01/01/2019 - "Recent studies show that 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a metabolite formed from fish oil supplementation, was able to prevent and reverse high fat diet (HFD)-induced fatty liver in mice. "

Related Drugs and Biologics

1.	Acids
2.	furan
3.	Albumins
4.	Uremic Toxins
5.	Fish Oils
6.	Peptides (Polypeptides)
7.	Lipids
8.	Ligands
9.	Fatty Acids (Saturated Fatty Acids)
10.	indoxyl