SB 331750
a cathepsin K inhibitor; structure in first source
Also Known As:
5-(2-morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-(3-oxo-1-(2-(3-pyridin-2-yl-phenyl)-ethenoyl)-azepan-4-ylcarbanoyl)-butyl)-amide; SB-331750; SB331750
Networked: 2
relevant articles (1 outcomes,
1 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Bolognese, Brian J:
1 article
(06/2008)
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2. | Capper-Spudich, Elizabeth A:
1 article
(06/2008)
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3. | Carpenter, Donald C:
1 article
(06/2008)
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4. | Davis, T Gregg:
1 article
(06/2008)
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5. | Dong, Xiaoyang:
1 article
(06/2008)
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6. | Fox, Josephine H:
1 article
(06/2008)
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7. | Johanson, Roy A:
1 article
(06/2008)
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8. | Kurali, Edit:
1 article
(06/2008)
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9. | Locastro, Stephen M:
1 article
(06/2008)
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10. | Long, Edward:
1 article
(06/2008)
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Related Diseases
1. | Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
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2. | Experimental Arthritis
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3. | Bone Resorption
05/01/2002
- " Together, these data indicate that the cathepsin K inhibitor, SB 331750, prevented bone resorption in vivo and this inhibition resulted in prevention of ovariectomy-induced loss in trabecular structure." 05/01/2002
- " In vitro, SB 331750 partially, but dose-dependently, prevented the parathyroid hormone-induced hypercalcemia in an acute rat model of bone resorption. " 05/01/2002
- " In an in situ enzyme assay, SB 331750 inhibited osteoclast-associated cathepsin activity in tissue sections containing human osteoclasts (IC(50) approximately 60 nmol/L) and this translated into potent inhibition of human osteoclast-mediated bone resorption in vitro (IC(50) approximately 30 nmol/L). " 05/01/2002
- " In this study, a potent, nonpeptide inhibitor of rat cathepsin K (K(i) = 4.7 nmol/L), 5-(2-morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-(3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-ethenoyl]-azepan-4-ylcarbanoyl)-butyl)-amide (SB 331750), is described, which is efficacious in rat models of bone resorption. "
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4. | Hypercalcemia (Milk Alkali Syndrome)
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Related Drugs and Biologics
Related Therapies and Procedures