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KW 7158

an afferent nerve inhibitor

Also Known As:

KW-7158; N-(5,5-dioxo-10-oxo-4,10-dihydrothieno(3,2-c)(1)benzothiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Benzothiepins: 2
    - KW 7158: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiepins: 2
      - KW 7158: 3

Experts

1.	Fukuda, Ayumu: 2 articles (01/2014 - 11/2011)
2.	Nishiya, Yoichi: 2 articles (01/2014 - 11/2011)
3.	Shibata, Kenji: 2 articles (01/2014 - 11/2011)
4.	Yamagata, Tsuyoshi: 2 articles (01/2014 - 11/2011)
5.	Yokokawa, Sachiko: 2 articles (01/2014 - 11/2011)
6.	Kamigaki, Masayo: 1 article (01/2014)
7.	Sakuma, Takashi: 1 article (01/2014)
8.	Sasho, Setsuya: 1 article (01/2014)
9.	Sato, Hidetaka: 1 article (01/2014)
10.	Seishi, Takashi: 1 article (01/2014)

Related Diseases

1.	Overactive Urinary Bladder (Overactive Bladder) 11/01/2011 - "The generation of rat dorsal root ganglion cell lines to identify the target of KW-7158, a novel treatment for overactive bladder." 01/01/2014 - "KW-7158 is a novel therapeutic candidate for treating overactive bladder (OAB) with a unique mode of action: suppression of sensory afferent nerves. " 11/01/2011 - "KW-7158 is a drug candidate for the treatment of overactive bladder. " 01/01/2014 - "The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1."
2.	Urinary Incontinence 05/01/2012 - "Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: a pharmacokinetic study in male and female rats." 05/01/2012 - "To investigate the pharmacokinetics of KW-7158 (CAS 214763-95-8), a new drug candidate for urinary incontinence and bladder hyperactivity, in male and female rats, we developed and validated a simultaneous quantification method for KW-7158 and its 2 metabolites, M1 and M2, in plasma using high performance liquid chromatography-tandem mass spectrometry with positive/negative ion-switching scan mode. "

Related Drugs and Biologics

1.	Nucleosides