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NU2058

structure in first source

Also Known As:

O(6)-cyclohexylmethylguanine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        NU2058: 5

Experts

1.	Curtin, N J: 3 articles (01/2010 - 07/2000)
2.	Newell, D R: 2 articles (01/2010 - 07/2000)
3.	Robson, C N: 2 articles (01/2010 - 12/2007)
4.	Bentley, J: 1 article (01/2010)
5.	Johnson, N: 1 article (01/2010)
6.	Shapiro, G I: 1 article (01/2010)
7.	Wang, L-Z: 1 article (01/2010)
8.	Dolan, M Eileen: 1 article (05/2009)
9.	Harrison, Luke R E: 1 article (05/2009)
10.	Newell, David R: 1 article (05/2009)

Related Diseases

1.	Carcinogenesis 12/01/2022 - "Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis."
2.	Prostatic Neoplasms (Prostate Cancer) 12/06/2007 - "Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer."
3.	Neoplasms (Cancer) 07/27/2000 - "Against human tumor cells, NU2058 and NU6027 were growth inhibitory in vitro (mean GI50 values of 13 +/- 7 microM and 10 +/- 6 microM, respectively), with a pattern of sensitivity distinct from flavopiridol and olomoucine. "
4.	Head and Neck Neoplasms (Head and Neck Cancer) 05/15/2009 - "SQ20b, head and neck cancer cells were treated for 2h with NU2058 (100 microM) and then for a further 2h with cisplatin and NU2058. "
5.	Breast Neoplasms (Breast Cancer) 01/19/2010 - "The cellular effects of CDK2/1 siRNA knockdown and purine-based CDK2/1 inhibitors, NU2058 and NU6102, were measured in anti-estrogen-sensitive and resistant breast cancer cell lines. "

Related Drugs and Biologics

1.	Catenins
2.	Small Interfering RNA (siRNA)
3.	Estrogens (Estrogen)
4.	Cisplatin (Platino)
5.	Androgens
6.	4- cyclohexylmethoxy- 5- nitrosopyrimidine- 2,6- diamine
7.	NU6102
8.	olomoucine
9.	alvocidib (flavopiridol)
10.	purine