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PPA 250 (PA250)

inhibits dimerization of inducible nitric oxide synthase; structure in first source
Also Known As:
PA250; 3-(2,4-difluorophenyl)-6-(2-(4-(1H-imidazol-1-ylmethyl)phenoxy)ethoxy)-2-phenylpyridine; PPA-250
Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Al-Ayadhi, Laila: 1 article (10/2014)
2. Alfawaz, Hanan A: 1 article (10/2014)
3. Bhat, Ramesa Shafi: 1 article (10/2014)
4. El-Ansary, Afaf K: 1 article (10/2014)

Related Diseases

1. Body Weight (Weight, Body)
01/01/2023 - "Forty albino mice were divided into four groups of 10 animals each with two control and two treated groups of both sexes received only phosphate-buffered saline or a neurotoxic dose of PPA (250 mg/kg body weight) for 3 days, respectively. "
12/29/2022 - "The second group, which served as a propionic acid (PPA)-induced rodent model of ASD, received orally administered PPA (250 mg/kg body weight (BW)) for 3 days, followed by feeding with a standard diet until the end of the experiment. "
12/29/2022 - "The three other groups were given PPA (250 mg/kg body weight (BW)) for 3 days and then fed a standard diet and orally administered yogurt (3 mL/kg BW/day), artichokes (400 mL/kg BW/day), and a combination of Lacticaseibacillus rhamnosus GG at 0.2 mL daily (1 × 109 CFU; as the probiotic of yogurt) and luteolin (50 mg/kg BW/day; as the major antioxidant and anti-inflammatory ingredient of artichokes) for 27 days. "
10/25/2014 - "The fourth group received PPA 250 mg/Kg body weight/day for 3 days followed by alpha, 25-dihydroxyvitamin D (3) (1, 25-VD) for two weeks (Vitamin D therapeutic effect). "
10/25/2014 - "They were grouped into four equal groups of 7. The control group received only phosphate buffered saline; the oral buffered PPA-treated group received a neurotoxic dose of 250 mg/kg body weight/day for 3 days; and the Vitamin D-protected group received 1000 IU/kg/day of alpha, 25-dihydroxyvitamin D (3) (1, 25-VD) for two weeks, after which the rats were injected with PPA 250 mg/Kg body weight/day for 3 days. "

Related Drugs and Biologics

1. Phosphates (Orthophosphate)
2. Luteolin
3. Therapeutic Uses
4. Vitamin D
5. Antioxidants
6. propionic acid (potassium propionate)