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cyclooxygenase-3

putative target of acetaminophen; lacks enzyme activity

Also Known As:

COX-3 enzyme; PTGS1b protein, human; cyclooxygenase-1b

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Prostaglandin-Endoperoxide Synthases: 6280
        cyclooxygenase-3: 3
  - Multienzyme Complexes: 8
    - Prostaglandin-Endoperoxide Synthases: 6280
      - cyclooxygenase-3: 3

Experts

1.	Atalar, Fatmahan: 1 article (01/2016)
2.	Bilir, Ayahan: 1 article (01/2016)
3.	Oksuz, Ersoy: 1 article (01/2016)
4.	Shahzadi, Andleeb: 1 article (01/2016)
5.	Tanırverdi, Gamze: 1 article (01/2016)
6.	Yazici, Zeliha: 1 article (01/2016)
7.	Aggarwal, Saurabh: 1 article (01/2012)
8.	Bhateja, Deepak: 1 article (01/2012)
9.	Dhull, Dinesh Kumar: 1 article (01/2012)
10.	Dhull, Rakesh K: 1 article (01/2012)

Related Diseases

1.	Cognitive Dysfunction 01/01/2012 - "The present study was designed to investigate the effects of chronic pretreatment with cyclooxygenase-1 or cyclooxygenase-2 or cyclooxygenase-3 selective inhibitors on cognitive dysfunction and oxidative stress markers in intracerebroventricular streptozotocin-treated rats. " 01/01/2012 - "Besides, improving cognitive dysfunction, chronic administration of highly selective cyclooxygenase-1 and/or cyclooxygenase-2 inhibitors (valeryl salicylate and etoricoxib, respectively), but not cyclooxygenase-3 inhibitor (phenacetin), significantly reduced elevated malondialdehyde, nitrite levels, and restored reduced glutathione and superoxide dismutase levels. "
2.	Neoplasms (Cancer) 01/01/2016 - "We also suggested that the inhibition of COX-3 enzyme may be responsible for decrease in tumor size in part, the mechanism by which acetaminophen and indomethacin decreased rat C6 glioblastoma growth. "
3.	Inflammation (Inflammations) 05/01/2010 - "These are a putative cyclooxygenase-3 which is a variant of cyclooxygenase-1 and derives from the same gene, and a COX-2 variant, induced with diclofenac, which may be involved in the resolution of inflammation."
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2016 - "Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma." 01/01/2016 - "We also suggested that the inhibition of COX-3 enzyme may be responsible for decrease in tumor size in part, the mechanism by which acetaminophen and indomethacin decreased rat C6 glioblastoma growth. "

Related Drugs and Biologics

1.	Cyclooxygenase 1
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Streptozocin (Streptozotocin)
4.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
5.	Superoxide Dismutase
6.	Salicylates
7.	Phenacetin
8.	Nitrites
9.	Malondialdehyde (Propanedial)
10.	Indomethacin (Indometacin)