cytochrome P-450 4X1

highly expressed in brain; GenBank AF439343

Also Known As:

CYP4X1

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        cytochrome P-450 4X1: 7
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - cytochrome P-450 4X1: 7
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        cytochrome P-450 4X1: 7

Experts

1.	Bell, David R: 2 articles (01/2017 - 04/2005)
2.	Brynychová, Veronika: 1 article (03/2021)
3.	Gatěk, Jiří: 1 article (03/2021)
4.	Hlaváč, Viktor: 1 article (03/2021)
5.	Kopečková, Katerina: 1 article (03/2021)
6.	Koževnikovová, Renata: 1 article (03/2021)
7.	Ostašov, Pavel: 1 article (03/2021)
8.	Souček, Pavel: 1 article (03/2021)
9.	Vrána, David: 1 article (03/2021)
10.	Václavíková, Radka: 1 article (03/2021)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 03/10/2021 - "In conclusion, the present study brings replicated association of variant rs17102977 in CYP4X1 with the response of patients to the neoadjuvant cytotoxic chemotherapy and warrants further research of genetic variation CYPs in breast cancer."
2.	Neoplasms (Cancer) 08/01/2010 - "The highest percentage of strong immunopositivity in breast cancers was seen for CYP4X1 (50.8%), CYP2S1 (37.5%) and CYP2U1 (32.2%), while CYP2J (98.6%) and CYP3A43 (70.7%) were the P450s that most frequently displayed no immunoreactivity. " 01/01/2018 - "These results suggest that CYP4X1 inhibition in TAMs by CH625 prolongs survival and normalizes tumor vasculature in glioma via CB2 and EGFR-STAT3 axis and may serve as a novel therapeutic strategy for human glioma." 01/01/2018 - "CYP27B1, CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS, ALOX12, and MAOB genes presented differential expression in the oral tumors. " 12/01/2020 - "A total of 30 differentially expressed genes (DEGs) were identified using the gene expression profiles from The Cancer Genome Atlas capecitabine and oxaliplatin treatment GC cases and seven key DEGs [uroplakin-1b (UPK1B), fatty acid-binding protein, heart (FABP3), cystatin-M, caspase-5 (CASP5), corticosteroid 11-β-dehydrogenase isozyme 2, cytochrome P450 4X1 (CYP4X1) and epidermal growth factor receptor kinase substrate 8-like protein 3] were associated with survival. "
3.	Hepatocellular Carcinoma (Hepatoma) 04/15/2005 - "In confluent cultures of human hepatoma HepG2 cells that stably express a mouse peroxisome proliferator activated receptor-alpha (PPARalpha) mutant, CYP4X1 mRNA was undetectable in vehicle-treated cells but was readily detectable following addition of the PPARalpha agonist Wy14643. "
4.	Glioma (Gliomas) 01/01/2018 - "These results suggest that CYP4X1 inhibition in TAMs by CH625 prolongs survival and normalizes tumor vasculature in glioma via CB2 and EGFR-STAT3 axis and may serve as a novel therapeutic strategy for human glioma." 01/01/2018 - "Here, we tested whether CYP4X1 inhibition in TAMs by flavonoid CH625 prolongs survival and normalizes glioma vasculature. " 01/01/2018 - "CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis."
5.	Body Weight (Weight, Body) 01/01/2017 - "The objective of the present investigation was to determine the impact of Cyp4x1 on body weight and energy metabolism by developing a line of transgenic Cyp4x1-knock out mice. "

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Uroplakin Ib
3.	Cystatin M
4.	Fatty Acid-Binding Proteins
5.	PPAR alpha
6.	Cytochrome P-450 CYP2E1 (CYP2E1)
7.	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)
8.	Messenger RNA (mRNA)
9.	Proteins (Proteins, Gene)
10.	Isoenzymes

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)