vernodalin

01/01/2013 - "To the best of our knowledge, this is the first comprehensive study on cytotoxic and apoptotic mechanism of vernodalin isolated from the Centratherum anthelminticum (L.) seeds in human breast cancer cells. "
12/08/2015 - "We also corroborated our findings in vivo by showing upregulation of p27Kip1, FOXO3a and decrease in the p-FOXO3a level in vernodalin-treated breast tumor tissue. "
12/08/2015 - "Silencing of FOXO3a protected breast cancer cells against vernodalin induced apoptosis. "
12/08/2015 - "Immunofluorescence, subcellular fractionation and Western blot showed FOXO3a accumulation in the nucleus of breast cancer cells after vernodalin treatment. "
12/08/2015 - "Furthermore, we showed that FOXO3a/PI3K-Akt played a significant role in vernodalin induced apoptosis in breast cancer cells. "

01/01/2022 - "The present study demonstrated the anti‑proliferative effect and apoptosis‑inducing activity of three sesquiterpene lactones isolated from Gymnanthemum extensum, vernodalin (VDa), vernolepin (VLe) and vernolide (VLi), on A549 human lung cancer cells. "

01/01/2023 - "Vernodalin (VN) induced apoptosis has been reported in various types of human cancer cells. "
01/01/2013 - "Overall, our data suggest a potential therapeutic value of vernodalin to be further developed as new anti-cancer drug."
01/01/2023 - "Vernodalin Suppresses Tumor Proliferation and Increases Apoptosis of Gastric Cancer Cells Through Attenuation of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways."
12/08/2015 - "The anti-tumor action of vernodalin was further confirmed by examining cell proliferative markers, PCNA and Ki67 in the LA7-induced mammary gland tumor model. "
12/08/2015 - "Our results showed that vernodalin regulates cancer cell apoptosis through activation of FOXO transcription factors and its downstream targets (Bim, p27Kip1, p21Waf1/cip1, cyclin D1, cyclin E) as examined by Western blots. "

12/01/2020 - "These results suggest that vernodalin could be developed as a potent chemotherapeutic agent for human colorectal cancer treatment."

01/01/2023 - "Vernodalin Suppresses Tumor Proliferation and Increases Apoptosis of Gastric Cancer Cells Through Attenuation of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways."