|1.||Saurer, Leslie: 1 article (04/2003)|
|2.||Mueller, Christoph: 1 article (04/2003)|
|3.||Arnold, Diana: 1 article (04/2003)|
|4.||Brunner, Thomas: 1 article (04/2003)|
|5.||Wasem, Christoph: 1 article (04/2003)|
|6.||Vallan, Claudio: 1 article (04/2003)|
|7.||Corazza, Nadia: 1 article (04/2003)|
|8.||Jakob, Sabine: 1 article (04/2003)|
|9.||Herren, Simon: 1 article (04/2003)|
|10.||Ohtsuka, Toshiaki: 1 article (08/2002)|
|1.||Autoimmune Diseases (Autoimmune Disease)
01/01/1999 - "Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases."
01/01/1999 - "Administration of bisindolylmaleimide VIII to rats during autoantigen stimulation prevented the development of symptoms of T cell-mediated autoimmune diseases in two models, the Lewis rat model of experimental allergic encephalitis and the Lewis adjuvant arthritis model. "
04/01/2003 - "Bisindolylmaleimide VIII (Bis VIII), a PKC inhibitor, can sensitize T cells for death receptor-induced apoptosis and thus can inhibit the development of T cell-mediated autoimmune disease in vivo. "
08/09/2002 - "These results suggest that the enhanced and persistent activation of the JNK/p38 and the decreased mitochondrial membrane potential play a crucial role in synergistic induction of the death receptor-mediated apoptosis by Bis VIII. The unique ability of Bis VIII to enhance DR5-mediated apoptosis signal transduction discloses a potential utility of this compound in combination with anti-DR5 antibody in cancer therapy."
04/01/2003 - "Importantly, Bis VIII administration during an acute lymphocytic choriomeningitis virus (LCMV) infection causes the depletion of virus-specific CD8+ T cells and subsequently impaired cytotoxicity and virus clearance. "
04/01/2003 - "We conclude that resistance to death receptor-induced apoptosis is crucial for the efficient induction of a protective immune response, and that Bis VIII-based immunotherapies have to be applied under well-controlled conditions to avoid the induction of immune incompetence and the inability to respond to pathogen infection."
|4.||Encephalitis (Encephalitis, Rasmussen)
|5.||Astrocytoma (Pilocytic Astrocytoma)
01/01/1999 - "Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human astrocytoma 1321N1 cells and in Molt-4T cells, both of which were devoid of apoptosis induced by anti-Fas antibody in the absence of bisindolylmaleimide VIII, and in Jurkat and CEM-6 T cells, which showed slight and moderate apoptotic responses, respectively, to low levels of Fas stimulation. "