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cytochrome P-450 CYP121

a cytochrome P-450 from Mycobacterium tuberculosis

Also Known As:

CYP121; CYP450 MT2

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        cytochrome P-450 CYP121: 7
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - cytochrome P-450 CYP121: 7
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        cytochrome P-450 CYP121: 7

Experts

1.	McLean, Kirsty J: 3 articles (01/2011 - 10/2002)
2.	Munro, Andrew W: 3 articles (01/2011 - 10/2002)
3.	Driscoll, Max D: 2 articles (01/2011 - 08/2010)
4.	Adam, Sebastian: 1 article (01/2021)
5.	Brengel, Christian: 1 article (01/2021)
6.	Gentilini, Maria Virginia: 1 article (01/2021)
7.	Hartmann, Rolf W: 1 article (01/2021)
8.	Kany, Andreas M: 1 article (01/2021)
9.	Köhnke, Jesko: 1 article (01/2021)
10.	Sparwasser, Tim: 1 article (01/2021)

Related Diseases

1.	Infections 08/01/2010 - "Gene essentiality for viability or host infection was demonstrated for Mtb P450s CYP128, CYP121 and CYP125. " 09/23/2022 - "In this study, with a focused view on implementing an in silico drug design pipeline, a diverse set of glycosylated flavonoids were screened against the Mtb cytochrome-P450 enzyme 121 (CYP121), which is established as an approved drug target for the treatment of Mtb infection. " 01/01/2011 - "These azoles are also the trio with the highest affinity for the essential CYP121 and for the cholesterol oxidase CYP125 (essential for host infection), and have high potency as anti-mycobacterial drugs. "
2.	Tuberculosis (Tuberculoses) 01/01/2021 - "CYP121 of Mycobacterium tuberculosis (Mtb) is an essential target for the development of novel potent drugs against tuberculosis (TB). " 04/01/2020 - "tuberculosis CYP121 inhibitors by the screening of Indonesian natural products using the principle of structure-based drug design and discovery. " 10/01/2002 - "tuberculosis CYP121, with K(d) values broadly in line with the MIC values for M. " 01/01/2018 - "tuberculosis cytochromes (Mtb CYP121). " 10/01/2002 - "tuberculosis H37Rv P450s encoded by genes Rv0764c (the sterol demethylase CYP51) and Rv2276 (CYP121). "

Related Drugs and Biologics

1.	Flavonoids
2.	Enzymes
3.	Sterols
4.	Cytochromes
5.	Cholesterol Oxidase
6.	Azoles