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demethylcantharidin

has antineoplastic activity; structure in first source

Also Known As:

7-oxabicyclo(2,1)heptane-2,3-dicarboxylic anhydride

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - Cantharidin: 597
        demethylcantharidin: 9

Experts

1.	Ho, Yee-Ping: 5 articles (06/2014 - 06/2005)
2.	Pang, Siu-Kwong: 4 articles (06/2014 - 03/2006)
3.	Au-Yeung, Steve C F: 4 articles (11/2008 - 06/2005)
4.	Yu, Chun-Wing: 3 articles (11/2008 - 03/2006)
5.	Fang, Qin: 1 article (01/2021)
6.	Tang, Rupei: 1 article (01/2021)
7.	Wang, Shi: 1 article (01/2021)
8.	Xu, Jiaxi: 1 article (01/2021)
9.	Xu, Xiaoxiao: 1 article (01/2021)
10.	Xue, Yanbing: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 06/08/2005 - "The results support a new approach for augmenting cytotoxic effect of established Pt-based drugs with demethylcantharidin in treating human hepatocellular carcinoma and other solid tumors." 06/01/2010 - "After A549 cells treated with ASO for 24 h and different concentrations of anti-cancer drug (cisplatin or demethylcantharidin) were added into culture medium, the results indicated the percentage of alive cells in group treated with both ASO-106 (or ASO-150) and anti-cancer drug was lower than that in group treated with ASO, or anti-cancer drug, or both ASO-16 (or ASO-34a) and anti-cancer drug. " 06/01/2013 - "A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer-(tandem drugs) conjugate for enhanced cancer treatment is demonstrated. " 01/01/2021 - "To achieve an ideal drug delivery platform with precise composition and high tumor selectivity, the PEGylated dual-drug backboned prodrug was synthesized via the copolymerization between diamine monomer of ortho ester and cisplatin- demethylcantharidin conjugate (Pt(IV)-1), and then terminated by mPEG550-active ester. "
2.	Colorectal Neoplasms (Colorectal Cancer) 11/09/2007 - "To investigate the likelihood of a novel dual mechanism of anticancer action, demethylcantharidin-integrated Pt complexes: Pt(R,R-DACH)(DMC) with the same Pt-DACH moiety as oxaliplatin, and Pt(NH(3))(2)(DMC) akin to carboplatin; were studied for their ability to induce DNA damage in HCT116 colorectal cancer cells by an alkaline comet assay. " 06/01/2014 - "The different types of cell death occurring in HCT116 colorectal cancer cell after the treatment of cisplatin, carboplatin, oxaliplatin, DMC, Pt(NH3)2(demethylcantharidin:DMC) and Pt(R,R-1,2-diaminocyclohexane: DACH)(DMC) were examined. "
3.	Necrosis 06/01/2014 - "East-west fusion-necrosis and apoptosis acting in concert by demethylcantharidin-integrated platinum complexes."
4.	Liver Neoplasms (Liver Cancer) 03/15/2006 - "A series of platinum complexes derived from integrating demethylcantharidin (DMC) with different isomers of 1,2-diaminocyclohexane (DACH) has been synthesized and found to exhibit superior in vitro anticancer activity against colorectal and human hepatocellular cancer cell lines when compared with oxaliplatin, cisplatin, and carboplatin. "
5.	Leukemia 06/08/2005 - "A novel series of TCM-platinum complexes [Pt(C8H8O5)(NH2R)2] 1-5, designed from incorporating demethylcantharidin, a modified component from a traditional Chinese medicine (TCM) with a platinum moiety was found to circumvent cisplatin resistance in mouse leukemia and human hepatocellular carcinoma. " 06/08/2005 - "We have investigated the potential synergistic effect of combining demethylcantharidin with a platinum-based antitumor agent, such as cisplatin, carboplatin, or oxaliplatin in vitro against L1210 mouse leukemia and SK-Hep-1 human hepatocellular carcinoma, and in vivo against a SK-Hep-1 subcutaneous-inoculated xenograft in nude mice, using median effect analysis. "

Related Drugs and Biologics

1.	Platinum
2.	Cisplatin (Platino)
3.	Oxaliplatin (Eloxatin)
4.	Carboplatin (JM8)
5.	1,2-cyclohexanediamine (dach)
6.	Prodrugs
7.	Polymers
8.	Esters
9.	Diamines
10.	Cantharidin (Cantharides)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Combination Drug Therapy (Combination Chemotherapy)