HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

PAR-1-activating peptide

Also Known As:

PAR-1-AP; TFLLR-NH2; threonyl-phenylalanyl-leucyl-leucyl-argininamide

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - PAR-1-activating peptide: 9

Experts

1.	Vergnolle, Nathalie: 2 articles (03/2003 - 03/2002)
2.	Fujimoto, Daisuke: 1 article (10/2015)
3.	Goi, Takanori: 1 article (10/2015)
4.	Hirono, Yasuo: 1 article (10/2015)
5.	Ueda, Yuki: 1 article (10/2015)
6.	Yamaguchi, Akio: 1 article (10/2015)
7.	Bièche, Ivan: 1 article (07/2015)
8.	Blandinières, Adeline: 1 article (07/2015)
9.	Cochain, Clément: 1 article (07/2015)
10.	Gaussem, Pascale: 1 article (07/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/27/2015 - "The selective PAR1 agonist TFLLR-NH2 induces an increase in the fraction of side population cells which is enriched in CSCs, and promotes tumorigenesis, multi cancer drug resistance, cell morphological change, and cell invasion which are characteristics of CSCs. " 07/01/2015 - "Finally, the postnatal vasculogenic stem cell derived from infantile hemangioma tumor (HemSC) incubated with PAR-1-ap increased leukocyte recruitment in Matrigel(®) implant. "
2.	Hyperalgesia 06/01/2002 - "The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats." 03/01/2002 - "Co-injection of PAR-1-AP with carrageenan significantly reduced carrageenan-induced mechanical and thermal hyperalgesia, while thrombin reduced carrageenan-induced mechanical but not thermal hyperalgesia. "
3.	Glioma (Gliomas) 12/01/2005 - "Cultured C6 rat glioma cells were stimulated with human alpha-thrombin or PAR-1-AP. " 12/01/2005 - "Both thrombin and its agonist, PAR-1-AP, significantly increased mRNA expression of pro-inflammatory cytokines in C6 glioma cells via PAR-1 activation." 11/01/2001 - "Here we have studied the effect of THR and PAR-1-activating peptide (PAR1-AP), SFLLRN, on cytokine-induced expression of inducible nitric oxide (iNOS), a prominent marker of astroglial activation using the rat C6 glioma cells. "
4.	Carcinogenesis 10/27/2015 - "The selective PAR1 agonist TFLLR-NH2 induces an increase in the fraction of side population cells which is enriched in CSCs, and promotes tumorigenesis, multi cancer drug resistance, cell morphological change, and cell invasion which are characteristics of CSCs. "
5.	Pneumonia (Pneumonitis) 01/01/2013 - "Activating PAR1 by administering the agonist TFLLR-NH2 decreased survival and increased lung inflammation after influenza infection. "

Related Drugs and Biologics

1.	Thrombin
2.	Cytokines
3.	Carrageenan
4.	Messenger RNA (mRNA)
5.	Peptides (Polypeptides)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	thrombin receptor peptide (42-47)
8.	matrigel