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benzyloxycarbonyltyrosyl- valyl- alanyl- aspartic acid fluoromethyl ketone

Also Known As:

Z-YVAD-FMK

Networked: 8 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Amino Acid Chloromethyl Ketones
    - benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone: 8

Experts

1.	Fan, Ruifang: 1 article (01/2022)
2.	Han, Hongyu: 1 article (01/2022)
3.	Huang, Chengmeng: 1 article (01/2022)
4.	Kuang, Hongxuan: 1 article (01/2022)
5.	Liu, Jian: 1 article (01/2022)
6.	Liu, Yungang: 1 article (01/2022)
7.	Pang, Qihua: 1 article (01/2022)
8.	Wang, Congcong: 1 article (01/2022)
9.	Wang, Lei: 1 article (01/2022)
10.	An, Zhen: 1 article (08/2021)

Related Diseases

1.	Atherosclerosis 01/01/2023 - "The current study investigated the therapeutic effects of inhibition of GSDMD activation by the novel GSDMD inhibitor N-Benzyloxycarbonyl-Leu-Leu-Ser-Asp(OMe)-fluoromethylketone (Z-LLSD-FMK), the specific caspase-1 inhibitor N-Benzyloxycarbonyl-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone (Z-YVAD-FMK), and a combination of both on atherosclerosis in ApoE-/- mice fed a western diet at 5 weeks of age, and further determined the efficacy of these polypeptide inhibitors in bone marrow-derived macrophages (BMDMs). "
2.	Neuroblastoma 01/01/2022 - "In this study, human neuroblastoma cell lines, IMR-32 and SK-N-SH cells, isolated from a male and a female subject, respectively, were exposed to BPA at various concentrations, with epigallocatechin gallate (EGCG, an antioxidant from green tea), Z-YVAD-FMK (a caspase-1 inhibitor), and ICI182.780 [an estrogen receptor (ER) inhibitor] as modulators. "
3.	Inflammation (Inflammations) 01/01/2023 - "These findings indicate that suppression of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and lesion development in ApoE-/- mice." 01/01/2023 - "Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE-/- mice." 12/01/2009 - "The involvement of caspase-4 in inflammation and apoptosis was further examined by treating the cells with caspase-4 inhibitor Z-LEVD-fmk, caspase-1 and -4 inhibitor Z-YVAD-fmk, and pan-caspase inhibitor Z-VAD-fmk. "
4.	Hypercapnia 01/05/2018 - "In addition, Z-YVAD-FMK, a caspase-1 inhibitor, was used to treat BV-2 microglia to determine whether activation of NLRP3 inflammasome was required for the enhancing effect of hypercapnia on expressing IL-1β by Western blotting or double immunofluorescence. "
5.	Dental Calculus 06/01/2018 - "Cell death induced by dental calculus was significantly inhibited by cytochalasin D, z-YVAD-fmk and glyburide, indicating NLRP3 inflammasome involvement. " 06/01/2018 - "For inhibition assays, the cells were exposed to dental calculus in the presence or absence of cytochalasin D (endocytosis inhibitor), z-YVAD-fmk (caspase-1 inhibitor) or glyburide (NLRP3 inflammasome inhibitor). "

Related Drugs and Biologics

1.	interleukin-1beta-converting enzyme inhibitor
2.	Therapeutic Uses
3.	Peptides (Polypeptides)
4.	Apolipoproteins E (ApoE)
5.	leucylleucine (Leu-Leu)
6.	alanylaspartic acid
7.	Caspase 1 (ICE Protease)
8.	Tea
9.	Estrogen Receptors
10.	Antioxidants