dioleyldimethylammonium chloride

structure in first source

Also Known As:

DODAC; dioleyldimonium chloride

Networked: 7 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Nitrogen Compounds: 67
  - Ammonium Compounds: 1606
    - Quaternary Ammonium Compounds: 136
      - dioleyldimethylammonium chloride: 7
Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - dioleyldimethylammonium chloride: 7
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - dioleyldimethylammonium chloride: 7
Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Monounsaturated Fatty Acids: 676
      - Oleic Acids: 67
        dioleyldimethylammonium chloride: 7

Experts

1.	Chierice, Gilberto Orivaldo: 3 articles (11/2018 - 01/2016)
2.	Luna, Arthur Cássio de Lima: 3 articles (11/2018 - 01/2016)
3.	Maria, Durvanei Augusto: 3 articles (11/2018 - 01/2016)
4.	Hesse, Henrique: 2 articles (11/2018 - 02/2018)
5.	Saraiva, Greice Kelle Viegas: 2 articles (11/2018 - 01/2016)
6.	Neto, Salvador Claro: 2 articles (02/2018 - 01/2016)
7.	Alves, M G: 1 article (10/2021)
8.	Cabral, Lgs: 1 article (10/2021)
9.	Conceição, T O: 1 article (10/2021)
10.	Laiso, Ran: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2000 - "In vivo studies using an intraperitoneal B16 tumor model and intraperitoneal administration of SPLP showed maximum transfection activity for SPLP containing 24 mol% DODAC. " 10/01/2021 - "The liposomal formulation DODAC/2-AEH2P has antitumor potential, inducing apoptosis in several tumor types. " 01/01/2016 - "DODAC demonstrated efficient PHO-S delivery, with the lowest values of IC50% (concentration that inhibits 50% of the growth of cells) for tumor cells, compared with PHO-S alone, with an IC50% value of 0.8 mM for B16F10 cells and 0.2 mM for Hepa1c1c7 cells, and without significant effects on endothelial cells. " 08/01/1999 - "In vivo studies employing an intraperitoneal B16 tumor model and intraperitoneal administration of SPLP also demonstrated maximum luciferase expression for DODAC contents of 20-24 mol% and significantly improved gene expression in tumor tissue as compared with complexes. " 11/01/2018 - "The overall results showed that DODAC/PHO-S liposomes were more effective than PHO-S alone, in promoting cytotoxicity Hepa1c1c7 tumor cells, activating the intrinsic and extrinsic pathways of programmed cell death."
2.	Melanoma (Melanoma, Malignant) 02/14/2018 - "The results of this study demonstrate that DODAC/PHO-S liposomes have exhibited broad cytotoxic potential in B16F10 murine melanoma cells, with significantly greater proportions than treatment with PHO-S. "
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/01/2021 - "Human chronic myeloid leukemia K-562 and K-562 Lucena (MDR+) cells were treated with the DODAC carrier and the liposomal formulation 2-AEH2P. "
4.	Rupture 10/01/2006 - "The additions of DODAC to ternary systems cause the rupture of alpha gel structures and transformation to vesicles. "
5.	Hepatocellular Carcinoma (Hepatoma) 11/01/2018 - "Therefore, our aim was to evaluate the potential of DODAC/PHO-S to elucidate the mechanism of cell death whereby the liposomes induces cytotoxicity in hepatocellular carcinoma Hepa1c1c7, compared to the PHO-S alone. " 11/01/2018 - "Antiproliferative and proapoptotic effects of DODAC/synthetic phosphoethanolamine on hepatocellular carcinoma cells."

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	Luciferases
3.	dimethyldioctadecylammonium (dimethyldioctadecylammonium chloride)
4.	phosphorylethanolamine (phosphoethanolamine)