protodioscin

from the rhizome of Dioscorea colletti (Dioscoreaceae); structure in first source

Also Known As:

NSC-698 796; NSC698796; beta-D-Glucopyranoside, (3beta,22beta,25R)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1->4))-

Networked: 20 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hsieh, Yi-Hsien: 2 articles (01/2022 - 01/2018)
2.	Guo, Changrun: 2 articles (12/2018 - 11/2016)
3.	Chiou, Hui-Ling: 1 article (01/2022)
4.	Lee, Hsiang-Lin: 1 article (01/2022)
5.	Lin, Ching-Pin: 1 article (01/2022)
6.	Wang, Shih-Wei: 1 article (01/2022)
7.	Yang, Shun-Fa: 1 article (01/2022)
8.	Yu, Chen-Lin: 1 article (01/2022)
9.	Buschinelli de Goes, Rafael Henrique de Tonissi: 1 article (05/2021)
10.	Dias, Alexandre Menezes: 1 article (05/2021)

Related Diseases

1.	Arthritis (Polyarthritis) 11/01/2017 - "We concluded that protodioscin administration into CFA-induced arthritis rats protected against CFA-induced oxidative stress, neutrophil infiltration, and inflammation, suggesting the anti-inflammatory effect and the therapeutic potential of protodioscin for arthritis." 11/01/2017 - "This study aimed to investigate the effect of protodioscin against Complete Freund's adjuvant (CFA)-induced arthritis rats. " 11/01/2017 - "Protodioscin ameliorates oxidative stress, inflammation and histology outcome in Complete Freund's adjuvant induced arthritis rats."
2.	Neoplasms (Cancer) 12/01/2022 - "Furthermore, protodioscin significantly inhibited tumor growth in vivo. " 04/01/2002 - "To systematically evaluate its potential anticancer activity, protodioscin was tested for cytotoxicity in vitro against 60 human cancer cell lines in the NCI's (National Cancer Institute, USA) anticancer drug screen. " 04/01/2002 - "Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel." 12/01/2022 - "Therefore, we aimed to examine the anti-cancer effects of protodioscin on bladder cancer. " 01/01/2023 - "Protodioscin (PD) is a steroidal saponin with various pharmacological activities, including neuro-protective, anti-inflammatory, and anti-tumor activities. "
3.	Inflammation (Inflammations) 04/28/2017 - "Moreover, the content of protodioscin (a well-known compound related to anti-inflammation activity) was elevated after fermentation of the AC extract at the optimized fermentation condition." 11/01/2017 - "We concluded that protodioscin administration into CFA-induced arthritis rats protected against CFA-induced oxidative stress, neutrophil infiltration, and inflammation, suggesting the anti-inflammatory effect and the therapeutic potential of protodioscin for arthritis." 11/01/2017 - "The histology, changes in biochemical parameters and inflammatory cytokines expression were detected for anti-inflammation effect evaluation of protodioscin. " 11/01/2017 - "Protective effect of protodioscin or methyl protodioscin against inflammation had been reported in various inflammation diseases. " 01/01/2016 - "Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis."
4.	Glucose Intolerance 11/15/2016 - "Protodioscin significantly improved glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. "
5.	Cerebral Infarction 01/01/2016 - "As compared with the operated rats without drug intervening, treatment with protodioscin apparently lowered the death rate and improved motor coordination abilities through reducing the deficit scores and cerebral infarct volume. "

Related Drugs and Biologics

1.	Saponins
2.	Freund's Adjuvant
3.	Neuroprotective Agents
4.	Estrogen Receptors
5.	Interferons
6.	dioscin
7.	Cytokines
8.	RNA (Ribonucleic Acid)
9.	Pilocarpine (Ocusert)
10.	Fructose