|1.||Wu, Kwan-Dun: 2 articles (01/2015 - 01/2013)|
|2.||Lai, Chun-Fu: 2 articles (01/2015 - 01/2013)|
|3.||Lin, Shuei-Liong: 2 articles (01/2015 - 01/2013)|
|4.||Chen, Yung-Ming: 2 articles (01/2015 - 01/2013)|
|5.||Chiang, Wen-Chih: 2 articles (01/2015 - 01/2013)|
|6.||Miao, Zhi-Feng: 2 articles (04/2014 - 09/2010)|
|7.||Glick, Adam B: 2 articles (04/2014 - 06/2011)|
|8.||Xu, Hui-Mian: 2 articles (04/2014 - 09/2010)|
|9.||Okumura, Meinoshin: 2 articles (11/2013 - 08/2013)|
|10.||Funaki, Soichiro: 2 articles (11/2013 - 08/2013)|
|1.||Prostatic Neoplasms (Prostate Cancer)
10/05/2015 - "To verify this hypothesis, we sought to examine p21 expression and cell growth in various cancer cells following the inhibition of autocrine TGF-β signaling using siRNAs targeting TGF-β signaling components and SB431542, a TGF-β receptor inhibitor. "
05/10/2015 - "Furthermore, administration of a TGFβR1 inhibitor (SB431542) significantly enhanced the growth of LLC tumors in WT mice compared with LRG KO mice via inhibition of apoptosis. "
12/01/2011 - "Then the protein levels of TGF-β in these cancer cells were detected by enzyme-linked immunosorbent assay, and the role of TGF-β signaling pathway in the effect of ionizing radiation on EMT was investigate by using the specific inhibitor SB431542. "
12/01/2010 - "CD8 T cells activated by human DCs treated with SB-431542 showed modest augmentation CTL activity against cancer cells. "
12/01/2010 - "Intraperitoneal administration of SB-431542 initiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. "
01/01/2007 - "In addition, the results of the present study indicated that over-expression of Dll1IC in embryonic carcinoma P19 cells induced neurons, and this induction was blocked by SB431542, which is a specific inhibitor of TGF-beta/Activin signaling. "
10/15/2007 - "In the mouse mammary carcinoma cell lines JygMC(A) and 4T1, the TGF-beta type I receptor kinase inhibitors A-44-03 and SB431542 induced apoptosis of cells under serum-free conditions. "
07/01/2002 - "To evaluate the relative contribution of Smad signaling and p38 MAPK signaling in TGF-beta1-induced matrix production, the effect of SB-431542 was compared with that of SB-242235 in renal epithelial carcinoma A498 cells. "
|4.||Neoplasm Metastasis (Metastasis)
01/30/2015 - "Using an in vivo liver metastasis model of pancreatic cancer, we observed that blocking Nodal signaling activity with the small-molecule inhibitor SB431542 decreases the number and size of liver metastases. "
01/01/2015 - "The differentially expressed proteins in the comparison of lung metastases from SB-431542 treated and control vehicle-treated groups were analyzed by a quantitative LTQ Orbitrap Velos system coupled with stable isotope dimethyl labeling. "
01/01/2015 - "In the present study, we found that systemic administration of the TGF-β receptor kinase inhibitor, SB-431542, significantly inhibited lung metastasis from transplanted 4T1 mammary tumors in Balb/c mice. "
12/01/2015 - "MPO-derived oxidative stress also activates transforming growth factor β (TGF-β) in vitro, and TGF-β signaling inhibition with SB-431542 decreased steatosis and fibrosis in vivo. "
12/01/2004 - "Furthermore, as an anti-TGFbeta agent, SB431542 may represent a potential new approach to the treatment of fibrosis."
10/01/2005 - "Thus, SB-431542 and Smad3/siRNA may be potential therapeutics for fibrosis."
01/01/2015 - "Upregulation of these TGF-β signaling components correlated with upregulation of fibrosis markers collagen 1 and fibronectin, responses that were inhibited by administration of the TGF-β receptor 1 inhibitors SB431542 or GW788388. "
|1.||Transforming Growth Factor beta (TGF-beta)
|4.||Transforming Growth Factors (Transforming Growth Factor)
|5.||Transforming Growth Factor beta1 (TGF beta 1)
|9.||Transforming Growth Factor beta Receptors (TGF beta Receptors)
|10.||Messenger RNA (mRNA)