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Suc-HSA

substitution of human serum albumin with negatively charged molecule of succinic acid

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Albumins: 31532
    - Serum Albumin: 9893
      - Human Serum Albumin: 2275
        Suc-HSA: 3
  - Blood Proteins: 12459
    - Serum Albumin: 9893
      - Human Serum Albumin: 2275
        Suc-HSA: 3
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Succinates: 13
        Suc-HSA: 3

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/1996 - "The present pharmacokinetic and toxicologic data of Suc-HSA and Aco-HSA show that both compounds are interesting preparations for studies in SIV infected monkeys and AIDS patients."
2.	Human Influenza (Influenza) 04/04/1997 - "Aco-HSA and Suc-HSA markedly inhibited the rates and extents of fusion of fluorescently labeled virosomes bearing influenza HA, with target membranes derived from erythrocytes. "
3.	Infections 01/01/1997 - "Suc-HSA was also evaluated for its in vivo neutralizing capacity in a human-to-mouse chimeric model for HIV-1 infection. " 01/01/1997 - "Intraperitoneal injections of 300 and 3 mg/kg Suc-HSA, given 15-30 min before the mice were challenged with the virus, sufficed to protect these mice against infection with the HIV-1 IIIB strain." 01/01/1997 - "Negatively charged albumins (NCAs, with the prototypes succinylated human serum albumin (Suc-HSA) and aconitylated human serum albumin (Aco-HSA)), modified proteins with a potent anti-human immunodeficiency virus type 1 (anti-HIV-1) activity in vitro, were studied for their pharmacokinetic behaviour in mice and their in vivo anti-HIV-1 efficacy in an HIV-1 infection model in mice. "

Related Drugs and Biologics

1.	polyaconitylated human serum albumin
2.	Virosomes
3.	Proteins (Proteins, Gene)
4.	Albumins
5.	Human Serum Albumin

Related Therapies and Procedures

1.	Intraperitoneal Injections