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indocarbazostatin B

an inhibitor of nerve growth stimulated by nerve growth factor; isolated from Streptomyces; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        indocarbazostatin B: 1
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - indocarbazostatin B: 1

Experts

1.	Feng, Yufei: 1 article (04/2002)
2.	Matsuura, Nobuyasu: 1 article (04/2002)
3.	Nakajima, Noriyuki: 1 article (04/2002)
4.	Tamehiro, Norimasa: 1 article (04/2002)
5.	Ubukata, Makoto: 1 article (04/2002)

Related Diseases

1.

Pheochromocytoma

04/01/2002 - "Two novel indolocarbazol-type bioactive molecules, indocarbazostatin (1) and indocarbazostatin B (2), were isolated as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells from a culture broth of a Streptomyces sp. The structures of these compounds were determined by HR-FAB-MS, UV, 1H and 13C NMR, 1H-1H COSY, PFG HMBC, PFG HMQC and DIF NOE experiments. "

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	indocarbazostatin
3.	vitamin B 12 factor III (HMQC)