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3'- O- tert- butyldimethylsilyl- 2',5'- dideoxy- 5'- oxothymidine

structure in first source

Also Known As:

3-TBS-DOT

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Silicon Compounds: 11
  - Silanes: 142
    - 3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-oxothymidine: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-oxothymidine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - 3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-oxothymidine: 1
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - 3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-oxothymidine: 1

Experts

1.	Andrei, G: 1 article (12/2001)
2.	Balzarini, J: 1 article (12/2001)
3.	De Clercq, E: 1 article (12/2001)
4.	Dilda, P: 1 article (12/2001)
5.	Kovacs, I: 1 article (12/2001)
6.	Seman, M: 1 article (12/2001)
7.	Snoeck, R: 1 article (12/2001)
8.	Tronchet, J M: 1 article (12/2001)

Related Diseases

1.

Dehydration (Water Stress)

12/01/2001 - "Treatment of 3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-oxothymidine (4) with potassium or magnesium nitromethanide afforded in good yield the resolvable epimeric mixture of the expected blocked nitronucleosides 5 which upon dehydration led to the corresponding E-nitroenofuranosylthymidine 6. Nucleophilic attack of cyanide onto the nitrovinyl group led to a nucleoside analogue bearing a terminal 1-cyanovinyl group (7), a soft electrophilic group which, upon reaction with benzeneselenol, underwent a conjugate addition to the phenylselenonucleoside derivative 9. All these compounds, eventually de-O-silylated, were subject of in vitro biological testing, some exhibiting interesting cytotoxic or antiviral properties."

Related Drugs and Biologics

1.	Potassium
2.	Nucleosides
3.	Magnesium
4.	Cyanides (Isocyanides)
5.	Antiviral Agents (Antivirals)
6.	benzeneselenol