methyl protoneodioscin
furostanol saponin from the rhizome of Dioscorea collettii
Also Known As:
NSC 698,791; NSC-698791
Networked: 1
relevant articles (1 outcomes,
0 trials/studies)
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Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Neoplasms (Cancer)
03/01/2002
- " In order to systematically evaluate its potential anticancer activity, methyl protoneodioscin cytotoxicity was tested in vitro against 60 human cancer cell lines in the NCI's (National Cancer Institute, USA) anticancer drug screen. " 03/01/2002
- " The cytotoxicity of methyl protoneodioscin (NSC-698791) against human cancer cell lines in vitro." 03/01/2002
- " Methyl protoneodioscin (NSC-698791) is a furostanol saponin isolated from the rhizome of Dioscorea collettii var. hypoglauca (Dioscoreaceae), a Chinese herbal remedy for the treatment of cervical carcinoma, carcinoma of the urinary bladder and renal tumor for centuries. " 03/01/2002
- " As a result, methyl protoneodioscin was cytotoxic against all the test cell lines from leukemia and solid tumors in the NCI's human cancer panel, especially selectively against one non-small cell lung cancer (NSCLC) line (A549/ATCC), one colon cancer line (HCT-116), two central nenous system (CNS) cancer lines (SF-539 and SNB-75), one melanoma line (M14), one renal cancer line (CAKI-1), one prostate cancer (DU-145) and two breast cancer lines (HS 578T and MDA-MB-435) with GI50 < or = 2.0 microM. "
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2. | Carcinoma (Carcinomatosis)
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3. | Prostatic Neoplasms (Prostate Cancer)
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4. | Melanoma (Melanoma, Malignant)
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5. | Leukemia
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