trimethylguanosine synthase

catalyzes the hypermethylation of the 5' m(7)G cap structure of snRNA and snoRNA

Also Known As:

TGS1 protein, S cerevisiae; TGS1 protein, human; YPL157W protein, S cerevisiae; trimethyl guanosine synthase

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Benetti, Roberta: 1 article (01/2022)
2.	Bonazza, Deborah: 1 article (01/2022)
3.	Bottin, Cristina: 1 article (01/2022)
4.	Broccia, Pamela Veneziano: 1 article (01/2022)
5.	Buemi, Valentina: 1 article (01/2022)
6.	Cacchione, Stefano: 1 article (01/2022)
7.	Cortale, Maurizio: 1 article (01/2022)
8.	Del Sal, Giannino: 1 article (01/2022)
9.	Dell'Omo, Giulia: 1 article (01/2022)
10.	Kengne, Sylvie: 1 article (01/2022)

1.	Postmenopausal Osteoporosis 01/01/2022 - "The protein-protein interaction network identified the key proteins, and the correlation analysis of these proteins and the bone parameters found histone deacetylase 8(HDAC8) and leucine-rich transmembrane and O-methyltransferase domain containing (LRTOMT) and trimethylguanosine synthase 1(TGS1) and ankyrin repeat domain 46(ANKRD46) to be the key targets of exercise in relation to postmenopausal osteoporosis. "
2.	Neoplasms (Cancer) 01/01/2022 - "Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5' end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2022 - "Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5' end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance. "

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Proteins (Proteins, Gene)
3.	Methyltransferases
4.	Leucine (L-Leucine)
5.	Histone Deacetylases (Histone Deacetylase)
6.	telomerase RNA (bTR)
7.	N(2),N(2),7-trimethylguanosine