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N(4)- (2,2- dimethyl- 1- methylcarbamoylpropyl)- N(1)- hydroxy- 2- hydroxymethyl- 3- (4- methoxyphenyl)succinamide

inhibits both TNF-alpha converting enzyme and matrix metalloproteinases; structure in first source
Also Known As:
(2S,3R)-N(4)-((S)-2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide; N(4)-DMHHMPSucc; PKF242-484; TNF484
Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Trifilieff, Alexandre: 2 articles (09/2007 - 04/2002)
2. Neumann, Ulf: 2 articles (01/2007 - 04/2002)
3. Teixeira, Mauro M: 1 article (09/2007)
4. Andrade, Marcus Vinícius Melo: 1 article (09/2007)
5. Ferreira, Flávio Lopes: 1 article (09/2007)
6. Amaral, Flávio A: 1 article (09/2007)
7. Fagundes, Caio T: 1 article (09/2007)
8. Vieira, Angélica T: 1 article (09/2007)
9. Lisboa, Rodolfo Assis: 1 article (09/2007)
10. Souza, Danielle G: 1 article (09/2007)

Related Diseases

1. Inflammation
2. Reperfusion Injury
3. Seizures (Seizure)
4. Pneumonia (Pneumonitis)
5. Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)

Related Drugs and Biologics

1. tumor necrosis factor-alpha convertase
2. Matrix Metalloproteinases
3. N(4)- (2,2- dimethyl- 1- methylcarbamoylpropyl)- N(1)- hydroxy- 2- hydroxymethyl- 3- phenylsuccinamide