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poricoic acid A

from Poria cocos (Polyporaceae); structure in first source

Networked: 14 relevant articles (1 outcomes, 4 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - poricoic acid A: 14

Experts

1.	Chen, Lin: 6 articles (11/2022 - 01/2019)
2.	Chen, Dan-Qian: 5 articles (07/2020 - 01/2019)
3.	Zhao, Ying-Yong: 5 articles (07/2020 - 01/2019)
4.	Vaziri, Nosratola D: 4 articles (07/2020 - 01/2019)
5.	Wang, Ming: 3 articles (12/2019 - 01/2019)
6.	Hu, He-He: 2 articles (07/2020 - 01/2020)
7.	Wang, Yan-Ni: 2 articles (07/2020 - 01/2020)
8.	Cao, Gang: 2 articles (12/2019 - 01/2019)
9.	Feng, Ya-Long: 2 articles (12/2019 - 01/2019)
10.	Guo, Yan: 2 articles (12/2019 - 01/2019)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 04/01/2021 - "Previous studies have shown that poricoic acid A (PAA), the main chemical constituent on the surface layer of the mushroom Poria cocos, has protective effects against oxidative stress and acute kidney injury. "
2.	Hypoxia (Hypoxemia) 01/01/2019 - "In this study, the effects of melatonin or poricoic acid A (PAA) and their combination were investigated in protecting against AKI-to-CKD transition in rats and hypoxia/reoxygenation (H/R)-induced injury in cultured renal NRK-52E cells. " 01/01/2019 - "Here, we examined the renoprotective effects of melatonin and poricoic acid A (PAA) isolated from the surface layer of Poria cocos, and investigated the effects of combined therapy on the interaction of TGF-β/Smad and Wnt/β-catenin in a rat model of renal ischemia-reperfusion injury (IRI) and hypoxia/reoxygenation (H/R) or TGF-β1-induced HK-2 cells. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "The present study was conducted to explore the anticancer effects and the underlying mechanisms of poricoic acid A (PAA), the main components of Poria cocos, on ovarian cancer. " 01/01/2021 - "Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis."
4.	Neoplasms (Cancer) 10/13/2023 - "In this study, the anti-tumor activities of poricoic acid A (PAA) and poricoic acid B (PAB), purified by high-speed counter-current chromatography, as well as their mechanisms and signaling pathways, were investigated using a HepG2 cell model. "
5.	Fibrosis (Cirrhosis) 07/01/2020 - "Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis." 09/14/2023 - "Poricoic acid A (PAA), a component isolated from Traditional Chinese Medicine (TCM) Poria cocos, has hypoglycaemic and anti-fibrosis effects. " 01/01/2023 - "Retracted: Poricoic Acid A Inhibits the NF-κB/MAPK Pathway to Alleviate Renal Fibrosis in Rats with Cardiorenal Syndrome." 01/01/2022 - "To explore the potential and mechanism of action of poricoic acid A (PAA) in treatment of cardiorenal injury and fibrosis due to cardiorenal syndrome (CRS). " 01/01/2022 - "Poricoic Acid A Inhibits the NF-κB/MAPK Pathway to Alleviate Renal Fibrosis in Rats with Cardiorenal Syndrome."

Related Drugs and Biologics

1.	Melatonin
2.	Acids
3.	Catenins
4.	Sirtuin 3
5.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
6.	Sucrose (Saccharose)
7.	kaempferide
8.	platelet-derived growth factor C (PDGF-C)
9.	dehydrotumulosic acid
10.	polygalaxanthone III

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Oral Administration