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HLFP regimen

used in patients with metastatic esophageal cancer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Therapy Context: Research Results

Experts

1.	André, Thierry: 1 article (01/2003)
2.	Beerblock, Karine: 1 article (01/2003)
3.	Cady, Jean: 1 article (01/2003)
4.	Carrat, Fabien: 1 article (01/2003)
5.	Gamelin, Erick: 1 article (01/2003)
6.	Louvet, Christophe: 1 article (01/2003)
7.	Mabro, May: 1 article (01/2003)
8.	Mal, Frédéric: 1 article (01/2003)
9.	Vaillant, Jean-Christophe: 1 article (01/2003)
10.	de Gramont, Aimery: 1 article (01/2003)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 01/01/2003 - "Prognostic factor analysis in advanced gastric cancer patients treated with hydroxyurea, leucovorin, 5-fluorouracil, and cisplatin (HLFP regimen)."
2.	Neoplasms (Cancer) 03/01/2002 - "Optimisation of 5-fluorouracil (5-FU)/cisplatin combination chemotherapy with a new schedule of hydroxyurea, leucovorin, 5-FU and cisplatin (HLFP regimen) for metastatic oesophageal cancer."
3.	Esophageal Neoplasms (Esophageal Cancer) 03/01/2002 - "To improve the efficacy and tolerance of the 5-fluorouracil (5-FU)/cisplatin combination in metastatic esophageal cancer, we designed a new therapeutic schedule, the HLFP regimen. "
4.	Deglutition Disorders (Dysphagia) 03/01/2002 - "The HLFP regimen consisted of twice-monthly oral administration of hydroxyurea 1 g/m(2) on days 0, 1 and 2; a 2-h infusion of leucovorin 200 mg/m(2) and a bolus of 5-FU 400 mg/m(2) followed by a 22-h infusion of 5-FU 600 mg/m(2) on days 1 and 2; and, every two cycles, 80 mg/m(2) cisplatin on day 3. Relief of dysphagia and other symptoms were monitored, together with body weight changes. "
5.	Carcinoma (Carcinomatosis) 03/01/2002 - "These results suggest that the HLFP regimen is an active and well-tolerated chemotherapy for metastatic oesophageal carcinoma."

Related Drugs and Biologics

1.	Hydroxyurea (Hydrea)
2.	Fluorouracil (Carac)
3.	Leucovorin (Folinic Acid)
4.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration