vitilevuamide

a bicyclic 13 amino acid peptide from two marine ascidians, Didemnum cuculiferum and Polysyncranton lithostrotum; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 08/01/2008 - "Didemnin was the first marine peptide that entered in human clinical trials in US for the treatment of cancer and other compounds such as dolastatin-10, soblidotin, didemnin B, ecteinascidin 743, girolline, aplidine, cryptophycins (also arenastatin A), bryostatin 1, ILX 651, kahalalide F, E7389, discodermolide, ES-285 (spisulosine), HTI-286 (hemiasterlin derivative), squalamine, KRN-7000, vitilevuamide, Laulimalide, Curacin A, diazonamide, peloruside A, eleutherobin, sarcodictyin, thiocoraline, salicylihalimides A, ascididemnin, CGX-1160, CGX-1007dictyodendrins, GTS-21 (aka DMBX), manoalide, IPL-576,092 (aka HMR-4011A) have entered in the clinical trials. "
2.	Tetraploidy 02/15/2002 - "Cell cycle analysis showed that vitilevuamide arrested cells in the G(2)/M phase with 78% of treated cells tetraploid after 16hr. "
3.	Lymphoid Leukemia 02/15/2002 - "Vitilevuamide was active in vivo against P388 lymphocytic leukemia, increasing the lifespan of leukemic mice 70% at 30 microg/kg. We hypothesized that at least part of the cytotoxic mechanism of vitilevuamide was due to its inhibition of tubulin polymerization. "

1.	Depsipeptides
2.	Peptides (Polypeptides)
3.	Trabectedin
4.	girolline
5.	tasidotin
6.	HTI-286
7.	hemiasterlin
8.	peloruside A
9.	spisulosine
10.	Conus geographus contulakin-G protein