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AMD 6221

a nitric oxide scavenger; structure in first source

Also Known As:

(Ru(H(3)DTPA)(Cl)); AMD-6221; AMD6221

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bisland, Stuart K: 1 article (09/2011)
2.	Flitney, Frederick W: 1 article (09/2011)
3.	Fricker, Simon P: 1 article (09/2011)
4.	Hirst, David G: 1 article (09/2011)
5.	Kennovin, Gordon D: 1 article (09/2011)
6.	Pritchard, Rebecca J: 1 article (09/2011)

Related Diseases

1.

Neoplasms (Cancer)

09/01/2011 - "L-NAME, AMD6221, and AMD6245 reduced tumor growth by approximately 60% to 75% of control rates. "
09/01/2011 - "Tumor-bearing animals were treated with (i) nitric oxide synthase (NOS) inhibitors, administered via the drinking water, including N(G)-nitro-l-arginine methyl ester (L-NAME), a nonisoform-selective inhibitor, and 2 others that target the inducible (NOS II) enzyme preferentially, namely 1-amino-2-hydroxyguanidine or N-[3-(aminomethyl)benzyl]acetamidine hydrochloride; or (ii) daily injections (intraperitoneally) of 2 Ru(III) polyaminocarboxylates, AMD6221 and AMD6245, both of which are effective NO scavengers. "

Related Drugs and Biologics

1.	Drinking Water
2.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
3.	NG-Nitroarginine Methyl Ester (L-NAME)
4.	Nitric Oxide Synthase (NO Synthase)
5.	Enzymes
6.	1-amino-2-hydroxyguanidine
7.	acetamidine

Related Therapies and Procedures

1.	Injections