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carboxyphenylglycine
structure in first source
Also Known As:
CPG cpd
Networked:
9
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Glycine: 5151
carboxyphenylglycine: 9
Experts
1.
Dąbrowska-Bouta, Beata
: 1 article (01/2013)
2.
Strużyńska, Lidia
: 1 article (01/2013)
3.
Sulkowski, Grzegorz
: 1 article (01/2013)
4.
Moreira, Thiago S
: 1 article (10/2011)
5.
Takakura, Ana C
: 1 article (10/2011)
Related Diseases
1.
Tetanus
11/01/1995 - "
The mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine [(+)MCPG] did not convert a subthreshold tetanus into a suprathreshold tetanus, nor did (+)MCPG have any effect on the small amount of LTP that was generated by a just suprathreshold tetanus.
"
11/01/1993 - "
The specific mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), applied at a concentration of 250 or 500 microM, reduced the size of the Ca2+ transient whilst either producing a small reduction or, more commonly, having no effect on the synaptic current evoked by the tetanus.
"
2.
Status Epilepticus (Complex Partial Status Epilepticus)
03/01/2023 - "
The mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine injected intracerebroventricularly increased the sensitivity and severity of pentylenetetrazole-induced status epilepticus, whereas application of the mGluR1 antagonist (+)-2-methyl-4-carboxyphenylglycine (LY367385) alleviated the severity of pentylenetetrazole-induced status epilepticus.
"
3.
Ischemia
02/01/1999 - "
(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats monolaterally infused with NMDA into the caudate nucleus; and (iii) gerbils subjected to transient global ischemia.
"
4.
Hypoglycemia (Reactive Hypoglycemia)
05/01/1994 - "
The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia.
"
5.
Hypercapnia
10/01/2011 - "
Bilateral injection of the non-NMDA receptor antagonist 6,7-dinitro-quinoxaline-2,3-dione (DNQX; 100 mm in 50 nl) and the metabotropic receptor antagonist (+/-)-α-methyl-4-carboxyphenylglycine (MCPG; 100 mm in 50 nl) in the RTN did not affect sympathoexcitatory responses induced by hypercapnia.
"
Related Drugs and Biologics
1.
Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.
N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.
metabotropic glutamate receptor type 1
4.
alpha-methyl-4-carboxyphenylglycine
5.
N-Methylaspartate (NMDA)
6.
Pentylenetetrazole (Metrazol)
7.
Memantine (Namenda)
8.
Amantadine (Aman)
9.
Acids
10.
FG 9041 (DNQX)